CCNK and DVL3

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CCNK	DVL3
Description		cyclin K	dishevelled segment polarity protein 3
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin K-CDK12 Complex Cyclin K-CDK13 Complex Nucleus Nucleoplasm Cyclin/CDK Positive Transcription Elongation Factor Complex	Nuclear Chromatin Cytosol
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Protease Binding Signaling Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Rac GTPase Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Protein Phosphorylation Cellular Response To DNA Damage Stimulus Cell Cycle Positive Regulation Of DNA-templated Transcription, Elongation SnRNA Transcription By RNA Polymerase II Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Cell Division Positive Regulation Of Phosphorylation Of RNA Polymerase II C-terminal Domain Serine 2 Residues	Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Neuron Projection Arborization Regulation Of Cellular Protein Localization Beta-catenin Destruction Complex Disassembly
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat HIV elongation arrest and recovery Pausing and recovery of HIV elongation SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase II Transcription Elongation	TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Scalp hair shape ( 26926045) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Major depressive disorder ( 22472876)
Interacting Genes		25 interacting genes: ATXN1 BHLHE40 CCDC85B CDK18 CDK2 CDK9 CEP76 DVL3 EFEMP2 FKBP6 HMG20A KCNRG KRTAP4-12 LZTS2 NDC80 NECAB2 PIN1 POLR2A RBPMS RFX6 RHOXF2 STX11 TLE5 TSC22D4 USHBP1	49 interacting genes: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RAB18 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697
Entrez ID		8812	1857
HPRD ID		10352	03222
Ensembl ID		ENSG00000090061	ENSG00000161202
Uniprot IDs		A0A024R6K1 O75909	Q92997 Q9UG07
PDB IDs		2I53 4CXA 4NST 4UN0 5ACB 5EFQ 6B3E 6CKX
Enriched GO Terms of Interacting Partners?
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