CREG1 and IGF2R

Number of citations of the paper that reports this interaction (PubMedID 12934103)
16

Data Source:
HPRD (in vitro)

		CREG1	IGF2R
Description		cellular repressor of E1A stimulated genes 1	insulin like growth factor 2 receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Transcription Factor Complex Azurophil Granule Lumen Extracellular Exosome	Nuclear Envelope Lumen Lysosomal Membrane Endosome Early Endosome Late Endosome Golgi Apparatus Trans-Golgi Network Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Membrane Clathrin Coat Transport Vesicle Endocytic Vesicle Trans-Golgi Network Transport Vesicle Clathrin-coated Vesicle Membrane Secretory Granule Membrane Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Transcription Factor Binding Cofactor Binding	G-protein Alpha-subunit Binding Retinoic Acid Binding Insulin-like Growth Factor-activated Receptor Activity Protein Binding Insulin-like Growth Factor Binding Mannose Binding Enzyme Binding Insulin-like Growth Factor II Binding Signaling Receptor Activity Identical Protein Binding Phosphoprotein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Regulation Of Growth Neutrophil Degranulation Negative Regulation Of Nucleic Acid-templated Transcription	Liver Development Receptor-mediated Endocytosis Lysosomal Transport Signal Transduction G Protein-coupled Receptor Signaling Pathway Spermatogenesis Post-embryonic Development Animal Organ Regeneration Response To Retinoic Acid Positive Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation By Host Of Viral Process Insulin-like Growth Factor Receptor Signaling Pathway Membrane Organization
Pathways		Neutrophil degranulation	Golgi Associated Vesicle Biogenesis Neutrophil degranulation Retrograde transport at the Trans-Golgi-Network Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs			Mecasermin alpha-D-mannose 6-phosphate Cerliponase alfa
Diseases			Hepatocellular carcinoma
GWAS		Blood protein levels ( 30072576 29875488)	Blood protein levels ( 30072576 29875488 28240269) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Brain lesion load ( 19010793) Coronary artery disease ( 29212778) Lipoprotein (a) levels ( 26377243) Periodontitis (CDC/AAP) ( 24024966) Serum metabolite concentrations in chronic kidney disease ( 29545352)
Interacting Genes		7 interacting genes: ATP1B1 CAPN1 IGF2R RB1 RBL1 RBL2 TBP	14 interacting genes: AGA ATXN1 CREG1 CSNK2A1 CTSD GGA1 GGA2 GGA3 GZMB IGF2 PACS1 PLAU PLAUR PLIN3
Entrez ID		8804	3482
HPRD ID		09897	00928
Ensembl ID		ENSG00000143162	ENSG00000197081
Uniprot IDs		O75629	P11717
PDB IDs		1XHN	1E6F 1GP0 1GP3 1GQB 1JPL 1JWG 1LF8 2CNJ 2L29 2L2A 2M68 2M6T 2V5N 2V5O 2V5P 5IEI 6N5X 6N5Y
Enriched GO Terms of Interacting Partners?
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