TNFSF10 and TNFRSF10C

Number of citations of the paper that reports this interaction (PubMedID 9314565)
117

Data Source:
HPRD (in vivo, in vitro)

		TNFSF10	TNFRSF10C
Description		TNF superfamily member 10	TNF receptor superfamily member 10c
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Integral Component Of Plasma Membrane Extracellular Exosome	Plasma Membrane Cell Surface Anchored Component Of Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Identical Protein Binding TRAIL Binding	Transmembrane Signaling Receptor Activity TRAIL Binding
	Biological Process	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Male Gonad Development Response To Insulin Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	TRAIL-activated Apoptotic Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process
Pathways		Caspase activation via Death Receptors in the presence of ligand Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited Dimerization of procaspase-8 TRAIL signaling	TP53 Regulates Transcription of Death Receptors and Ligands
Drugs
Diseases
GWAS		Breast cancer ( 28171663) Breast cancer (estrogen-receptor negative) ( 28171663) Carotid plaque burden ( 28282560) Cocaine dependence ( 31212010) Height ( 28552196) Monocyte percentage of white cells ( 27863252) TRAIL levels ( 27989323) Triglycerides ( 30275531)	Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte count ( 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of granulocytes ( 27863252) Sum basophil neutrophil counts ( 27863252) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252) White blood cell count (basophil) ( 27863252)
Interacting Genes		9 interacting genes: ACP5 CASP3 RBM48 TNFRSF10A TNFRSF10B TNFRSF10C TNFRSF10D TNFRSF11B ZDHHC17	10 interacting genes: APOA1 LMNA LRSAM1 RAP1A RFLNB SLC27A6 SRPK1 SRPK2 TNFSF10 ZHX1
Entrez ID		8743	8794
HPRD ID		04670	04681
Ensembl ID		ENSG00000121858	ENSG00000173535
Uniprot IDs		P50591 Q6IBA9	O14798
PDB IDs		1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
Enriched GO Terms of Interacting Partners?
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