CBFB and CBFA2T2

Number of citations of the paper that reports this interaction (PubMedID 9447981)
41

Data Source:
HPRD (in vitro, in vivo)

		CBFB	CBFA2T2
Description		core-binding factor subunit beta	CBFA2/RUNX1 partner transcriptional co-repressor 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Core-binding Factor Complex	Nucleus
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding	DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Osteoblast Differentiation Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Lymphocyte Differentiation Myeloid Cell Differentiation Regulation Of Wnt Signaling Pathway Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Regulatory T Cell Differentiation Regulation Of Keratinocyte Differentiation Regulation Of Myeloid Cell Differentiation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Regulation Of B Cell Receptor Signaling Pathway Definitive Hemopoiesis Regulation Of Hematopoietic Stem Cell Differentiation Regulation Of Bicellular Tight Junction Assembly	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Projection Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Intestinal Epithelial Cell Differentiation
Pathways		RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Transcriptional regulation by RUNX2 Transcriptional regulation by RUNX2 RUNX1 regulates estrogen receptor mediated transcription Regulation of RUNX1 Expression and Activity RUNX1 regulates expression of components of tight junctions RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of HSCs RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 regulates transcription of genes involved in differentiation of keratinocytes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known RUNX1 regulates transcription of genes involved in BCR signaling RUNX1 regulates transcription of genes involved in differentiation of myeloid cells RUNX1 regulates transcription of genes involved in interleukin signaling RUNX1 regulates transcription of genes involved in WNT signaling Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity RUNX2 regulates osteoblast differentiation RUNX2 regulates osteoblast differentiation RUNX2 regulates chondrocyte maturation RUNX2 regulates bone development RUNX2 regulates genes involved in cell migration RUNX2 regulates genes involved in cell migration RUNX2 regulates genes involved in differentiation of myeloid cells Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF Estrogen-dependent gene expression Transcriptional regulation of granulopoiesis
Drugs
Diseases
GWAS		Mean corpuscular hemoglobin ( 27863252)	Height ( 28552196)
Interacting Genes		9 interacting genes: CBFA2T2 CHGB COPRS CUL5 RAB2A RNF7 RUNX1 RUNX2 RUNX3	22 interacting genes: APP ATN1 ATXN1L CBFA2T3 CBFB FBXL19 GTF2E1 ID3 LBP MDFI NCOR1 NCOR2 NEUROG1 NOTCH3 NTAQ1 PDP1 RERE RUNX1 SIN3A TAL2 TCP1 ZNF652
Entrez ID		865	9139
HPRD ID		00418	04721
Ensembl ID		ENSG00000067955	ENSG00000078699
Uniprot IDs		A0A024R6X2 Q13951	O43439
PDB IDs		1CL3 1E50 1H9D 4N9F
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?