RUNX2 and ALYREF

Number of citations of the paper that reports this interaction (PubMedID 9119228)
91

Data Source:
BioGRID (pull down)

		RUNX2	ALYREF
Description		RUNX family transcription factor 2	Aly/REF export factor
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol	Transcription Export Complex Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Exon-exon Junction Complex Extracellular Exosome Catalytic Step 2 Spliceosome
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding ATP Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Repressing Transcription Factor Binding	RNA Binding Protein Binding
	Biological Process	Ossification Osteoblast Differentiation Endochondral Ossification Osteoblast Fate Commitment Chondrocyte Differentiation Chondrocyte Development Osteoblast Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Cell Proliferation Hemopoiesis Neuron Differentiation T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Embryonic Forelimb Morphogenesis Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Odontogenesis Of Dentin-containing Tooth Regulation Of Odontogenesis Of Dentin-containing Tooth Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Embryonic Cranial Skeleton Morphogenesis Stem Cell Differentiation Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus	Regulation Of DNA Recombination MRNA Splicing, Via Spliceosome Osteoblast Differentiation RNA Export From Nucleus MRNA Export From Nucleus Viral Process MRNA 3'-end Processing Replication Fork Processing Positive Regulation Of DNA-templated Transcription, Elongation Viral MRNA Export From Host Cell Nucleus
Pathways			Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs
Diseases		Cleidocranial dysplasia
GWAS		Central corneal thickness ( 29760442) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) facial morphology traits (multivariate analysis) ( 27193062) Height ( 25429064 18391951) Hip minimal joint space width ( 27701424) Hip shape (DXA scan) ( 30320955) Intraocular pressure ( 29785010 30054594) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Mosquito bite size ( 28199695) Osteoarthritis (hip) ( 30374069) Periodontal microbiota ( 22699663) Progressive supranuclear palsy ( 30089514) Survival in pancreatic cancer ( 28470677)
Interacting Genes		38 interacting genes: ALYREF AR AXIN1 CBFB CCNB1 CDK1 CEBPB DVL2 EP300 ETS1 FHL2 FOS HDAC3 HDAC4 HDAC6 HDAC7 HIF1A HIVEP3 JUN KAT6B LEF1 MAP3K4 MSX2 PRIM2 PRKCD RB1 RBM14 SMAD2 SMAD3 SMAD6 SMURF2 SOX9 STUB1 TAF1A UBTF XRCC5 XRCC6 YAP1	10 interacting genes: AKT1 DDX39B ESR1 IL7R LEF1 MAGOH NXF1 RUNX2 THOC6 UPF3A
Entrez ID		860	10189
HPRD ID		02566	09168
Ensembl ID		ENSG00000124813	ENSG00000183684
Uniprot IDs		A0A0D9SEN7 Q13950 Q32MY8	E9PB61 Q86V81
PDB IDs			3ULH
Enriched GO Terms of Interacting Partners?
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