PRKRA and ZNF746

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		PRKRA	ZNF746
Description		protein activator of interferon induced protein kinase EIF2AK2	zinc finger protein 746
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm RISC-loading Complex	Nucleus Cytoplasm
	Molecular Function	RNA Binding Double-stranded RNA Binding Protein Binding Enzyme Activator Activity Enzyme Binding Identical Protein Binding Protein Homodimerization Activity Pre-miRNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Ubiquitin Protein Ligase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Immune Response Negative Regulation Of Cell Proliferation Response To Virus MiRNA Metabolic Process Viral Process Production Of SiRNA Involved In RNA Interference Pre-miRNA Processing Cellular Response To Oxidative Stress Production Of MiRNAs Involved In Gene Silencing By MiRNA Outer Ear Morphogenesis Middle Ear Morphogenesis Positive Regulation Of Catalytic Activity Skeletal System Morphogenesis Protein Stabilization Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuron Death
Pathways		MicroRNA (miRNA) biogenesis Small interfering RNA (siRNA) biogenesis	Generic Transcription Pathway
Drugs
Diseases		Primary torsion dystonia (PTD)
GWAS		Inflammatory skin disease ( 25574825) Multiple sclerosis (OCB status) ( 23472185) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183)	Amyotrophic lateral sclerosis ( 19451621) Multiple sclerosis ( 21833088)
Interacting Genes		21 interacting genes: AGO2 CEBPZ CEP126 COPS6 DICER1 EIF2AK2 GDF9 LYAR NKRF POLR2G RABEPK RB1 SETDB1 SHC1 SNX5 TARBP2 TIRAP TP53 ZFP28 ZMAT3 ZNF746	14 interacting genes: DIABLO DUSP23 EPHA8 FAM118B FES GSK3B HMOX2 ILK MAP3K20 MAP3K7 PRKN PRKRA RPS6KA6 UBE2E3
Entrez ID		8575	155061
HPRD ID		04573	08099
Ensembl ID		ENSG00000180228	ENSG00000181220
Uniprot IDs		B4DJC7 O75569	Q6NUN9
PDB IDs		2DIX
Enriched GO Terms of Interacting Partners?
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