MADD and PIDD1

Number of citations of the paper that reports this interaction (PubMedID 10825539)
18

Data Source:
HPRD (in vivo)

		MADD	PIDD1
Description		MAP kinase activating death domain	p53-induced death domain protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol
	Molecular Function	Death Receptor Binding Protein Binding Rab Guanyl-nucleotide Exchange Factor Activity Protein Kinase Activator Activity	Endopeptidase Activity Death Receptor Binding Protein Binding
	Biological Process	Activation Of MAPK Activity Cell Surface Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Rab Protein Signal Transduction Regulation Of Apoptotic Process Regulation Of Cell Cycle Execution Phase Of Apoptosis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Signal Transduction Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Protein Autoprocessing Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways			TP53 Regulates Transcription of Caspase Activators and Caspases
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) C-reactive protein levels ( 30388399) Chronic kidney disease ( 26831199) Chronotype ( 30696823) Corneal astigmatism ( 29422769) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Fasting blood proinsulin levels ( 23263489) General factor of neuroticism ( 30867560) Glaucoma (primary open-angle) ( 29891935) Glycemic traits (pleiotropy) ( 31021400) HDL cholesterol ( 19060911 25961943) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Neuroticism ( 29255261) Proinsulin levels ( 21873549)	Breast cancer ( 29059683)
Interacting Genes		10 interacting genes: NPDC1 PIDD1 POT1 PTPRN RB1CC1 TNFRSF10A TNFRSF10B TNFRSF1A VPS13D YWHAZ	13 interacting genes: AFP CASP2 CCDC85B CRADD EFEMP2 FADD KEAP1 MADD MAFG MDFI MTNR1B SOX8 TEAD3
Entrez ID		8567	55367
HPRD ID		04664	11284
Ensembl ID		ENSG00000110514	ENSG00000177595
Uniprot IDs		A0A0A0MRB5 Q8WXG6	Q9HB75
PDB IDs			2OF5
Enriched GO Terms of Interacting Partners?
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