BHLHE40 and AANAT

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		BHLHE40	AANAT
Description		basic helix-loop-helix family member e40	aralkylamine N-acetyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Cytoplasm Nuclear Body	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity E-box Binding	Aralkylamine N-acetyltransferase Activity Arylamine N-acetyltransferase Activity Protein Binding 14-3-3 Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Circadian Rhythm Anterior/posterior Pattern Specification Cell Differentiation Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Regulation Of Neurogenesis	N-terminal Protein Amino Acid Acetylation Circadian Rhythm Response To Light Stimulus Photoperiodism Response To Zinc Ion Melatonin Biosynthetic Process Response To Insulin Response To Cytokine Response To Prostaglandin E Indolalkylamine Biosynthetic Process Response To Copper Ion Response To Corticosterone Response To Calcium Ion Cellular Response To CAMP
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression	Serotonin and melatonin biosynthesis
Drugs			Coa-S-Trimethylene-Acetyl-Tryptamine Coa-S-Acetyl Tryptamine Coa-S-Acetyl 5-Bromotryptamine
Diseases			Delayed sleep phase syndrome
GWAS		Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244) Psoriasis vulgaris ( 26626624) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252)
Interacting Genes		51 interacting genes: AAMP AANAT APH1A ARNTL BHLHE41 BRD7 CALML3 CCNK CDPF1 CHD3 COX5B DAB1 EHHADH ENO1 FBLN1 GMCL2 HDAC1 HIVEP1 HNRNPLL KRTAP23-1 LARP4 MAGED1 MYOD1 NAA50 NOC4L NUMBL PDE6G PLEKHB2 PRKAA1 RBFOX1 RBM23 RBPMS RHOBTB3 RHOJ SETDB1 SIN3A SMARCB1 SMYD1 SOX15 STAT3 STK19 TCF3 TLE5 TOB2 TOLLIP TTC23 TXNL4B UBE2I VAC14 VIM ZHX1	5 interacting genes: BHLHE40 F2 MDFI PRKACA YWHAZ
Entrez ID		8553	15
HPRD ID		16050	02974
Ensembl ID		ENSG00000134107	ENSG00000129673
Uniprot IDs		O14503 Q6IB83	F1T0I5 Q16613
PDB IDs
Enriched GO Terms of Interacting Partners?
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