STON2 and SYT1

Number of citations of the paper that reports this interaction (PubMedID 11381094)
61

Data Source:
HPRD (in vitro)

		STON2	SYT1
Description		stonin 2	synaptotagmin 1
Image
GO Annotations	Cellular Component	Nucleolus Cytosol Synaptic Vesicle Membrane Cell Junction Clathrin-coated Vesicle Neuron Projection	Cytoplasm Golgi Apparatus Plasma Membrane Synaptic Vesicle Cell Junction Integral Component Of Synaptic Vesicle Membrane Axon Clathrin-coated Vesicle Membrane Synaptic Vesicle Membrane Dense Core Granule Chromaffin Granule Membrane Presynaptic Membrane Neuron Projection Neuron Projection Terminus Excitatory Synapse Clathrin-sculpted Acetylcholine Transport Vesicle Membrane Clathrin-sculpted Glutamate Transport Vesicle Membrane Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Clathrin-sculpted Monoamine Transport Vesicle Membrane Exocytic Vesicle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Protein Binding	SNARE Binding Phosphatidylserine Binding Calcium Ion Binding Protein Binding Calmodulin Binding Calcium-dependent Phospholipid Binding Phosphatidylinositol-4,5-bisphosphate Binding Protein C-terminus Binding Syntaxin-1 Binding Syntaxin Binding Clathrin Binding Syntaxin-3 Binding Identical Protein Binding Protein Heterodimerization Activity Calcium-dependent Protein Binding Low-density Lipoprotein Particle Receptor Binding Calcium Ion Sensor Activity
	Biological Process	Hematopoietic Progenitor Cell Differentiation Regulation Of Endocytosis Synaptic Vesicle Endocytosis Membrane Organization	Detection Of Calcium Ion Chemical Synaptic Transmission Neurotransmitter Secretion Brain Development Glutamate Secretion Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Vesicle-mediated Transport Calcium Ion Regulated Exocytosis Regulation Of Exocytosis Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Dopamine Secretion Vesicle Docking Synaptic Vesicle Endocytosis Calcium Ion-regulated Exocytosis Of Neurotransmitter Positive Regulation Of Synaptic Transmission Protein Heterooligomerization Regulation Of Synaptic Transmission, Glutamatergic Membrane Organization Spontaneous Neurotransmitter Secretion Cellular Response To Calcium Ion Synchronous Neurotransmitter Secretion Fast, Calcium Ion-dependent Exocytosis Of Neurotransmitter Calcium-dependent Activation Of Synaptic Vesicle Fusion Positive Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Regulation Of Regulated Secretory Pathway Positive Regulation Of Dendrite Extension
Pathways		Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Toxicity of botulinum toxin type B (BoNT/B) Toxicity of botulinum toxin type G (BoNT/G) Neurexins and neuroligins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis GABA synthesis, release, reuptake and degradation
Drugs
Diseases
GWAS		Central corneal thickness ( 29760442) Estimated glomerular filtration rate ( 31152163) Metabolite levels ( 23823483) Night sleep phenotypes ( 27126917) Obesity-related traits ( 23251661) Platelet count ( 27863252) Plateletcrit ( 27863252) Prudent dietary pattern ( 28644415)	Chloride levels ( 29403010) Estimated glomerular filtration rate ( 31217584) General cognitive ability ( 29844566) Hand grip strength ( 29313844) Intelligence (MTAG) ( 29326435) Lysophosphatidylcholine levels ( 31551469) Obesity-related traits ( 23251661) Pulse pressure ( 30578418) QRS duration ( 31251759) Sodium levels ( 29403010) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653)
Interacting Genes		6 interacting genes: AP2M1 EPS15 EPS15L1 ITSN1 SYT1 SYT2	30 interacting genes: CACNA1A CACNB3 CACNB4 CALM1 FGF1 GOLM1 IKBKG IRF3 NEDD4 NR1H3 NR3C1 NRXN1 PPARG RACK1 RBM14 RIMS1 S100A13 SIN3A SMAD2 SNAP25 STON2 STX1A STX2 STX3 STX4 SV2B SYNCRIP SYT4 TFAP2A ZDHHC17
Entrez ID		85439	6857
HPRD ID		10531	01710
Ensembl ID		ENSG00000140022	ENSG00000067715
Uniprot IDs		A0A3B3IU55 Q8WXE9	A0A024RBE9 J3KQA0 P21579
PDB IDs		2JXC	2K45 2K4A 2K8M 2KI6 2LHA 2N1T 2R83 3F00 3F01 3F04 3F05 4ISQ 4V11 6G5F 6G5K
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?