RHPN2 and KRT18

Number of citations of the paper that reports this interaction (PubMedID 12473120)
5

Data Source:
HPRD (two hybrid, in vitro)

		RHPN2	KRT18
Description		rhophilin Rho GTPase binding protein 2	keratin 18
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Perinuclear Region Of Cytoplasm	Nucleolus Cytoplasm Microtubule Organizing Center Cytosol Intermediate Filament Adherens Junction Centriolar Satellite Keratin Filament Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery
	Molecular Function		RNA Binding Structural Molecule Activity Protein Binding Scaffold Protein Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Signal Transduction	Cell Cycle Anatomical Structure Morphogenesis Viral Process Keratinization Tumor Necrosis Factor-mediated Signaling Pathway Golgi To Plasma Membrane CFTR Protein Transport Negative Regulation Of Apoptotic Process Intermediate Filament Cytoskeleton Organization Cornification Extrinsic Apoptotic Signaling Pathway Hepatocyte Apoptotic Process Cell-cell Adhesion
Pathways		RHO GTPases Activate Rhotekin and Rhophilins RHO GTPases Activate Rhotekin and Rhophilins	Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Colorectal cancer ( 30529582 19011631 24836286 24737748) Colorectal cancer or advanced adenoma ( 30510241) Femoral neck bone mineral density ( 29499414) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414) Macular thickness ( 30535121) Obesity-related traits ( 23251661) Optic disc size ( 31809533)	Cleft lip with or without cleft palate ( 28054174) Diffusing capacity of carbon monoxide ( 30694715) Nonsyndromic cleft lip with cleft palate ( 28232668)
Interacting Genes		6 interacting genes: KRT18 RARG RHOA RHOB SMURF1 TGFBR1	78 interacting genes: BBS1 BBS2 BBS4 BBS7 CAMK2A CASP3 CASP6 CASP7 CASP8 CBL CCDC146 CCDC85B CCNI CDC5L CDK1 COL17A1 DEDD DNAJB6 EGFR EP300 ESR1 EXOC8 FRAT1 GIT2 GOLGA2 GRN HAUS1 HGS HRAS HSPA1A HSPA4 HSPA5 HSPB1 IKBKG KPNA2 KRT15 KRT5 KRT72 KRT8 LDOC1 MAPK14 NEFL NME7 ORC5 PDE4DIP PIAS4 PKD1 PKP2 PKP3 PNN POT1 PRKCA PRKCE PSTPIP2 RAF1 RHPN2 RPS6KA3 SERPINE1 SHC1 SMARCD1 SVIL SYCE1 TCHP TNFRSF1B TRADD TUBG1 TUBGCP4 TXN2 TXNDC11 UPF2 USH2A WBP2 YTHDC1 YWHAB YWHAE YWHAG YWHAH YWHAZ
Entrez ID		85415	3875
HPRD ID		10192	01020
Ensembl ID		ENSG00000131941	ENSG00000111057
Uniprot IDs		Q8IUC4	A0A024RAY2 P05783
PDB IDs		2VSV
Enriched GO Terms of Interacting Partners?
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