NKD1 and DVL3

Number of citations of the paper that reports this interaction (PubMedID 11274398)
64

Data Source:
HPRD (two hybrid, in vivo)

		NKD1	DVL3
Description		NKD inhibitor of WNT signaling pathway 1	dishevelled segment polarity protein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Protein Phosphatase Type 2A Complex Cytoplasm Plasma Membrane	Nuclear Chromatin Cytosol
	Molecular Function	Calcium Ion Binding Protein Binding PDZ Domain Binding	Protease Binding Signaling Receptor Binding Frizzled Binding Protein Binding Beta-catenin Binding Rac GTPase Binding
	Biological Process	Eye Photoreceptor Cell Differentiation Somatic Muscle Development Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Protein Catabolic Process Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Motility Involved In Somitogenic Axis Elongation Positive Regulation Of Non-canonical Wnt Signaling Pathway Via JNK Cascade Negative Regulation Of Convergent Extension Involved In Axis Elongation Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Positive Regulation Of Protein Phosphorylation Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Non-canonical Wnt Signaling Pathway Via JNK Cascade Response To Drug Positive Regulation Of JUN Kinase Activity Positive Regulation Of GTPase Activity Positive Regulation Of Transcription, DNA-templated Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Planar Cell Polarity Pathway Involved In Neural Tube Closure Positive Regulation Of Neuron Projection Arborization Regulation Of Cellular Protein Localization Beta-catenin Destruction Complex Disassembly
Pathways			TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		Copper levels ( 26025379) Crohn's disease ( 28067908 22412388) Inflammatory bowel disease ( 28067908) Systolic blood pressure ( 30224653)	Facial morphology traits (63 three-dimensional facial segments) ( 29459680) Major depressive disorder ( 22472876)
Interacting Genes		1 interacting genes: DVL3	49 interacting genes: ADAP1 AXIN1 BAHD1 C8orf33 CCNK CSNK1D CSNK1E CSNK2A1 CTNNB1 DAB2 DIDO1 DPPA2 DVL1 ENKD1 FAM13C KAT7 KLF3 KLHL12 LNX1 LRRK2 LY6H MARK2 MATN2 NKD1 NOL12 NXF1 PIK3CB PITX1 PLN PPM1A PPP2CA PRPF3 PSMF1 RAB18 RPS10 RWDD2B SNX22 STOM SYT6 TNFAIP8L1 UTP3 VANGL1 WT1 YTHDC1 ZBTB48 ZNF264 ZNF408 ZNF512B ZNF697
Entrez ID		85407	1857
HPRD ID		08482	03222
Ensembl ID		ENSG00000140807	ENSG00000161202
Uniprot IDs		Q969G9	Q92997 Q9UG07
PDB IDs
Enriched GO Terms of Interacting Partners?
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