KMT5C and RBL1

Number of citations of the paper that reports this interaction (PubMedID 15750587)
115

Data Source:
HPRD (in vitro)

		KMT5C	RBL1
Description		lysine methyltransferase 5C	RB transcriptional corepressor like 1
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GO Annotations	Cellular Component	Condensed Nuclear Chromosome, Centromeric Region Nucleus Nucleoplasm Nuclear Heterochromatin Pericentric Heterochromatin	Chromatin Nucleoplasm Transcription Factor Complex
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Histone Methyltransferase Activity (H4-K20 Specific) Metal Ion Binding S-adenosyl-L-methionine Binding	RNA Polymerase II Regulatory Region DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Transcription Factor Binding Promoter-specific Chromatin Binding
	Biological Process	DNA Repair Histone H4-K20 Trimethylation Positive Regulation Of Isotype Switching Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Cell Cycle Regulation Of Mitotic Cell Cycle Negative Regulation Of Gene Expression Viral Process Cell Differentiation Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cellular Senescence
Pathways		PKMTs methylate histone lysines	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest G1/S-Specific Transcription Cyclin D associated events in G1
Drugs
Diseases
GWAS			Height ( 25429064) Red cell distribution width ( 28957414)
Interacting Genes		4 interacting genes: H4C1 RB1 RBL1 RBL2	54 interacting genes: AOX1 BEGAIN BRCA1 BRF1 CCNA1 CCNA2 CCND1 CCNE1 CDK2 CDK4 CDK6 CEBPA CREG1 DGKZ DHX30 DYRK1A E2F1 E2F4 E2F5 EPHA2 FN1 GOLGA2 HDAC1 ID2 IRF3 KDM5A KMT5C LAMB2 MAPK6 MCM7 MYBL2 MYC NR2E3 NR4A1 NUCB1 PHB PLSCR1 PPP2R3A RBBP8 RBBP9 RINT1 SMAD2 SMAD3 SMAD4 SMARCA4 SNRPD3 SNW1 SP1 SUV39H1 TAF1 TOP1 TP53BP1 TSC22D2 USP4
Entrez ID		84787	5933
HPRD ID		15454	00312
Ensembl ID		ENSG00000133247	ENSG00000080839
Uniprot IDs		A0A0D9SF94 Q86Y97	P28749
PDB IDs		3RQ4	1H28 4YOO 4YOS 4YOZ 5TUV
Enriched GO Terms of Interacting Partners?
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