TPST2 and CCR1

Number of citations of the paper that reports this interaction (PubMedID 17558413)
22

Data Source:
HPRD (in vitro)

		TPST2	CCR1
Description		tyrosylprotein sulfotransferase 2	C-C motif chemokine receptor 1
Image
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Golgi Apparatus Integral Component Of Membrane	Cell Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Sulfotransferase Activity Protein-tyrosine Sulfotransferase Activity Protein Homodimerization Activity	Phosphatidylinositol Phospholipase C Activity Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding Chemokine (C-C Motif) Ligand 7 Binding Chemokine (C-C Motif) Ligand 5 Binding
	Biological Process	Peptidyl-tyrosine Sulfation 3'-phosphoadenosine 5'-phosphosulfate Metabolic Process	Dendritic Cell Chemotaxis Calcium Ion Transport Cellular Calcium Ion Homeostasis Exocytosis Chemotaxis Inflammatory Response Immune Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Response To Wounding Negative Regulation Of Gene Expression Cytokine-mediated Signaling Pathway Calcium-mediated Signaling Positive Regulation Of Cell Migration Negative Regulation Of Bone Mineralization Positive Regulation Of Osteoclast Differentiation Positive Regulation Of Calcium Ion Transport Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Monocyte Chemotaxis
Pathways		Cytosolic sulfonation of small molecules	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Anti-saccade response ( 29064472) Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483)	Behcet's disease ( 23291587) Celiac disease ( 22057235 20190752 18311140) Celiac disease and Rheumatoid arthritis ( 26546613) Heel bone mineral density ( 30598549) Inflammatory bowel disease ( 26192919) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Narcolepsy with cataplexy ( 25986216) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		5 interacting genes: CCR1 CCR8 CMKLR1 GPR1 SELPLG	20 interacting genes: CCL14 CCL15 CCL16 CCL2 CCL23 CCL26 CCL3 CCL3L1 CCL4 CCL5 CCL7 CCL8 CREB3 GNA14 JAK1 PLP2 STAT1 STAT3 TPST1 TPST2
Entrez ID		8459	1230
HPRD ID		07217	03101
Ensembl ID		ENSG00000128294	ENSG00000163823
Uniprot IDs		A0A024R1G9 O60704	P32246 Q5U003
PDB IDs		3AP1 3AP2 3AP3	1Y5D
Enriched GO Terms of Interacting Partners?
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