CASP9 and NLRP1

Number of citations of the paper that reports this interaction (PubMedID 11076957)
40

Data Source:
HPRD (in vivo)

		CASP9	NLRP1
Description		caspase 9	NLR family pyrin domain containing 1
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Protein-containing Complex Apoptosome	Nucleus Nucleoplasm Cytosol Inflammasome Complex NLRP1 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Enzyme Activator Activity Peptidase Activity SH3 Domain Binding Protein Kinase Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Domain Specific Binding
	Biological Process	Kidney Development Response To Ischemia Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To DNA Damage Stimulus Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process By Cytochrome C Platelet Formation Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Glial Cell Apoptotic Process Cellular Response To UV Signal Transduction In Response To DNA Damage Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Response To Antibiotic Cellular Response To Dexamethasone Stimulus Leukocyte Apoptotic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Response To DNA Damage Stimulus	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Viral Process Response To Muramyl Dipeptide Defense Response To Bacterium Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Neuron Apoptotic Process NLRP1 Inflammasome Complex Assembly
Pathways		Formation of apoptosome Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes NOD1/2 Signaling Pathway AKT phosphorylates targets in the cytosol Caspase activation via Dependence Receptors in the absence of ligand Constitutive Signaling by AKT1 E17K in Cancer Regulation of the apoptosome activity Regulation of the apoptosome activity	The NLRP1 inflammasome
Drugs
Diseases
GWAS		Alcoholic chronic pancreatitis ( 28754779) Estimated glomerular filtration rate ( 30604766) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Urate levels ( 31578528) Urinary metabolite levels in chronic kidney disease ( 31959995)	Migraine ( 27322543)
Interacting Genes		47 interacting genes: ABL1 AKT1 APAF1 ARNT BCL10 BCL2L1 BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 BIRC8 CAPN2 CARD8 CASP10 CASP12 CASP3 CASP7 CASP8 CYCS DCC DIABLO DSP GMEB1 GZMB HECTD3 HIP1 HSD17B4 HSPD1 ILK JUN LYN MAP2K1 MAP2K2 MAPK1 MAPK3 MSTO1 MZB1 NAIP NLRP1 NOD1 PRKCZ RB1 RNF2 SRF VIM XIAP	9 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD
Entrez ID		842	22861
HPRD ID		03756	07364
Ensembl ID		ENSG00000132906	ENSG00000091592
Uniprot IDs		F8VVS7 P55211	Q9C000
PDB IDs		1JXQ 1NW9 2AR9 3D9T 3V3K 3YGS 4RHW 5JUY 5WVC 5WVE	1PN5 3KAT 4IFP 4IM6 5Y3S
Enriched GO Terms of Interacting Partners?
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