CHD6 and TOLLIP

Number of citations of the paper that reports this interaction (PubMedID 20936779)
85

Data Source:
BioGRID (two hybrid)

		CHD6	TOLLIP
Description		chromodomain helicase DNA binding protein 6	toll interacting protein
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GO Annotations	Cellular Component	Nucleoplasm	Extracellular Region Cytoplasm Cytosol Nuclear Body Azurophil Granule Lumen Specific Granule Lumen Interleukin-18 Receptor Complex Interleukin-1 Receptor Complex Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Cofactor Binding DNA Binding DNA Helicase Activity ATP Binding DNA-dependent ATPase Activity	Interleukin-1, Type I Receptor Binding Protein Binding Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding SUMO Binding Toll-like Receptor Binding Ubiquitin Binding
	Biological Process	Chromatin Organization Viral Process DNA Duplex Unwinding Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress	Ubiquitin-dependent Protein Catabolic Process Autophagy Inflammatory Response Signal Transduction Cell-cell Signaling Phosphorylation Epithelial Cell Differentiation Positive Regulation Of Protein Sumoylation Intracellular Signal Transduction Protein Localization To Endosome Neutrophil Degranulation Innate Immune Response Leukocyte Activation Interleukin-1-mediated Signaling Pathway
Pathways			Neutrophil degranulation Interleukin-1 signaling
Drugs
Diseases
GWAS		Age-related cognitive decline (memory) (slope of z-scores) ( 30954325) Diastolic blood pressure ( 27841878) Gastric adenocarcinoma (histologically verified) ( 26098866) Hippocampal atrophy ( 22745009) Male-pattern baldness ( 28196072) Metabolite levels ( 23823483) Refractive astigmatism ( 30306274) Systolic blood pressure ( 27841878) Total cholesterol levels ( 30275531) Verbal declarative memory ( 25648963) Waist circumference ( 31170924)	Idiopathic pulmonary fibrosis ( 24429156)
Interacting Genes		6 interacting genes: ARAF ATXN1L H3-4 NFE2L2 TOLLIP ZFYVE9	44 interacting genes: ACTN2 ATXN1 BHLHE40 CHD6 CPSF6 CSN1S1 CSN2 CSTF1 DAB1 DAZAP2 DZIP3 EIF2AK2 FTH1 GGA1 GGA2 GGA3 HERPUD1 IL1R1 IL1RAP IRAK1 IRAK2 LDB1 N4BP2 NTAQ1 ODAM PEG10 PRR20A RBFOX2 RBPMS RHOXF2 SEPTIN1 SETDB1 SIAH1 TBX3 TLR2 TLR4 TOM1 TOM1L1 UBC WBP2 WRNIP1 XRN2 ZBTB16 ZHX1
Entrez ID		84181	54472
HPRD ID		13049	05887
Ensembl ID		ENSG00000124177	ENSG00000078902
Uniprot IDs		Q8TD26	B3KR28 E9PNS3 F2Z2Y8 Q6FIE9 Q8N8J5 Q9H0E2
PDB IDs		2EPB	1WGL 2N31
Enriched GO Terms of Interacting Partners?
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