ARID5B and USP54

		ARID5B	USP54
Description		AT-rich interaction domain 5B	ubiquitin specific peptidase 54
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Coactivator Activity Protein Binding Transcription Regulatory Region DNA Binding	Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Liver Development Regulation Of Transcription By RNA Polymerase II Nitrogen Compound Metabolic Process Male Gonad Development Female Gonad Development Post-embryonic Development Fibroblast Migration Adrenal Gland Development Multicellular Organism Growth Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Platelet-derived Growth Factor Receptor Signaling Pathway Cell Development Muscle Organ Morphogenesis Skeletal System Morphogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Roof Of Mouth Development Face Morphogenesis Adipose Tissue Development Fat Pad Development Positive Regulation Of Nucleic Acid-templated Transcription Cellular Response To Leukemia Inhibitory Factor	Protein Deubiquitination
Pathways		HDMs demethylate histones
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (B-cell precursor) ( 23996088) Acute lymphoblastic leukemia (childhood) ( 29348612 28817678 22076464 25310577 23512250 19684603 19684604) Acute lymphoblastic leukemia in childhood (B cell precursor) ( 29632299) Automobile speeding propensity ( 30643258) B-cell acute lymphoblastic leukaemia ( 31767839) Blood urea nitrogen levels ( 31152163) Central corneal thickness ( 31798171 29760442 30894546) Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025) Corneal resistance factor ( 30894546) Corneal structure ( 23291589) Diastolic blood pressure ( 19430483) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Medication use (thyroid preparations) ( 31015401) Plateletcrit ( 27863252) Reaction time ( 29844566) Response to haloperidol in psychosis ( 24751813) Rheumatoid arthritis ( 30423114 22446963 23143596 24390342) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Serum total protein level ( 23022100) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 27399966 23273568 26502338) Vitiligo ( 27723757)
Interacting Genes		1 interacting genes: USP54	21 interacting genes: ARID5B ATN1 ATXN1 CDK19 CFAP70 CHMP1B CHMP2A CHMP2B CHMP4C COMTD1 EIF4E2 FAM149B1 FUT11 HK1 MSS51 MSX2 NXT2 PLCD1 SAMD8 TTYH1 UBC
Entrez ID		84159	159195
HPRD ID		18880	15641
Ensembl ID		ENSG00000150347	ENSG00000166348
Uniprot IDs		Q14865	B7Z7X1 Q70EL1
PDB IDs		1IG6 2OEH
Enriched GO Terms of Interacting Partners?
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