PRAM1 and SKAP1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PRAM1	SKAP1
Description		PML-RARA regulated adaptor molecule 1	src kinase associated phosphoprotein 1
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Protein-containing Complex	Ruffle Immunological Synapse Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Microtubule Plus-end T Cell Receptor Complex Plasma Membrane Raft
	Molecular Function	Protein Binding Lipid Binding Protein Kinase Binding	SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Protein Kinase Binding Protein Phosphatase Binding SH2 Domain Binding Protein Homodimerization Activity Protein-containing Complex Binding Microtubule Plus-end Binding
	Biological Process	Integrin-mediated Signaling Pathway Regulation Of Neutrophil Degranulation T Cell Receptor Signaling Pathway Protein Localization To Plasma Membrane	Microtubule Cytoskeleton Organization Positive Regulation Of Cell-matrix Adhesion Adaptive Immune Response Positive Regulation Of Adaptive Immune Response Positive Regulation Of Signal Transduction Cell Migration Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Positive Regulation Of Leukocyte Cell-cell Adhesion
Pathways
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Height ( 18391951)	Body mass index ( 28892062 25673413) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Epithelial ovarian cancer ( 25581431) Food allergy ( 29030101) Generalized epilepsy ( 22949513) Intelligence ( 28530673) Lean body mass ( 28552196) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Ovarian cancer ( 20852632) Peanut allergy ( 29030101) Pulse pressure ( 30578418)
Interacting Genes		19 interacting genes: A2M ABI2 APOE APP CCDC57 CDC37 FXR2 KRT40 LCP2 LYN MAST1 MXD1 NEK6 PSEN1 RNF32 SKAP1 SKAP2 TRIM27 UBE2E2	15 interacting genes: APP BLCAP DYNLL2 ELOC FAM102A FYB1 FYN GRB2 LCK LYN PRAM1 PTPRC SH2D4A SRC TBKBP1
Entrez ID		84106	8631
HPRD ID		05926	05396
Ensembl ID		ENSG00000133246	ENSG00000141293
Uniprot IDs		Q96QH2	Q86WV1 V9HW03
PDB IDs			1U5D
Enriched GO Terms of Interacting Partners?
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