DTNBP1 and KANSL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DTNBP1	KANSL1
Description		dystrobrevin binding protein 1	KAT8 regulatory NSL complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Endosome Membrane Postsynaptic Density Microtubule Cytoskeleton Sarcoplasm Cell Junction Axon Growth Cone Midbody Synaptic Vesicle Membrane BLOC-1 Complex Melanosome Membrane Sarcolemma Neuron Projection Dendritic Spine Postsynaptic Membrane Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Axon Cytoplasm	Histone Acetyltransferase Complex Condensed Chromosome Kinetochore Nucleus Nucleoplasm NSL Complex MLL1 Complex
	Molecular Function	Protein Binding	Protein Binding Histone Acetyltransferase Binding Histone Acetyltransferase Activity (H4-K5 Specific) Histone Acetyltransferase Activity (H4-K8 Specific) Histone Acetyltransferase Activity (H4-K16 Specific)
	Biological Process	Positive Regulation Of Neurotransmitter Secretion Blood Coagulation Anterograde Axonal Transport Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Neuron Projection Development Actin Cytoskeleton Reorganization Negative Regulation Of Protein Binding Melanosome Organization Regulation Of JUN Kinase Activity Anterograde Synaptic Vesicle Transport Neuron Projection Morphogenesis Dendrite Morphogenesis Platelet Dense Granule Organization Regulation Of Dopamine Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Synaptic Vesicle Exocytosis	Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K16 Acetylation
Pathways		Golgi Associated Vesicle Biogenesis	HATs acetylate histones
Drugs
Diseases		Hermansky-Pudlak syndrome (HPS)
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Corneal astigmatism ( 30306274) Multiple myeloma ( 27363682) Squamous cell carcinoma ( 31174203)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease in APOE e4- carriers ( 25778476) Automobile speeding propensity ( 30643258) Breast cancer ( 29059683) Chronotype ( 30696823) Cognitive ability ( 29186694) Cognitive function ( 28093568) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) General factor of neuroticism ( 30867560) Hand grip strength ( 29313844) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Household income ( 31844048) Idiopathic pulmonary fibrosis ( 24429156) Lung function (FEV1) ( 28166213) Lung function (FVC) ( 28166213) Lung function (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Lymphocyte percentage of white cells ( 27863252) Macular thickness ( 30535121) Male-pattern baldness ( 27182965 28196072) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Neuroticism ( 29255261) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 27863252) Parkinson's disease ( 31660654 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pulse pressure ( 27841878) Reaction time ( 29844566) Red blood cell count ( 29403010) Red cell distribution width ( 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Risk-taking tendency (4-domain principal component model) ( 30643258) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878) Ventral diencephalon volume ( 31530798)
Interacting Genes		46 interacting genes: ABI3 AKAP6 ARFIP2 BICRAL BLOC1S5 BLOC1S6 BRF1 CCDC146 CCDC153 CCNA2 CCND3 CMYA5 DCTN1 DGCR6L DST DTNA DTNB ELOVL7 HAUS1 IFT20 IPO5 KALRN KANSL1 KIAA0408 KIFC3 MACF1 NBEA NDN NUF2 P4HA3 PSME3 RAB11A RBSN SDCBP SFR1 SHFL SNAPIN SRGAP3 SSC5D SYNE1 TRAF3IP1 TRIM2 TRIM27 TRIM9 WASHC3 ZNF490	35 interacting genes: CALCOCO2 CCDC136 CCDC85B CDC5L CDR2 CEP70 DISC1 DTNBP1 EXOC1 FSD2 GOLGA2 HOOK2 HSPB1 KAT8 KDM1A KIFC3 KRT15 MAGEA12 MDFI NECAB2 NINL NUP62 NUTM1 PLEKHA5 PNMA1 PSME3 RETREG3 SMAD3 SPAG5 TFIP11 TRAF2 TRAF4 TRIM27 USHBP1 WDR5
Entrez ID		84062	284058
HPRD ID		06190	11254
Ensembl ID		ENSG00000047579	ENSG00000120071
Uniprot IDs		A0A087WYP9 A0A0S2Z5U8 A6NFV8 D6RJC6 Q96EV8	A0A024R9Y2 A0A1W2PRB5 Q7Z3B3
PDB IDs			4CY1 4CY2
Enriched GO Terms of Interacting Partners?
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