CASP6 and PPL

Number of citations of the paper that reports this interaction (PubMedID 15654952)
5

Data Source:
HPRD (in vitro)

		CASP6	PPL
Description		caspase 6	periplakin
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Cornified Envelope Nucleus Cytoplasm Mitochondrion Cytosol Cytoskeleton Intermediate Filament Membrane Desmosome Extracellular Exosome
	Molecular Function	Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cadherin Binding
	Biological Process	Proteolysis Apoptotic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	Response To Mechanical Stimulus Wound Healing Intermediate Filament Cytoskeleton Organization Cornification
Pathways		Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases	Formation of the cornified envelope Butyrophilin (BTN) family interactions
Drugs
Diseases
GWAS		Risk-taking tendency (4-domain principal component model) ( 30643258)	Cancer ( 29299148) Diastolic blood pressure ( 28135244 27841878) Height ( 28552196) Lung cancer (asbestos exposure interaction) ( 22637743) Metabolite levels (HVA/MHPG ratio) ( 23319000) Mitochondrial DNA copy number (white blood cells) ( 30704525) Systolic blood pressure ( 27841878)
Interacting Genes		38 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 MAPK6 MAPT NEDD4 NUAK1 PCYT1A PIN1 PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	24 interacting genes: AHCYL1 AKT1 ALAS1 CASP6 CEP57L1 COL17A1 EVPL ITSN1 KAZN KRT8 LARP1 OPRM1 PPHLN1 PTEN RAB3IP RALBP1 SKIL TRAF2 TRIM27 TSC22D4 UBC USP7 VIM ZSCAN1
Entrez ID		839	5493
HPRD ID		03321	04187
Ensembl ID		ENSG00000138794	ENSG00000118898
Uniprot IDs		P55212	O60437
PDB IDs		1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV	4Q28
Enriched GO Terms of Interacting Partners?
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