CASP5 and NLRP1

Number of citations of the paper that reports this interaction (PubMedID 12191486)
1372

Data Source:
HPRD (in vitro, in vivo)

		CASP5	NLRP1
Description		caspase 5	NLR family pyrin domain containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm NLRP1 Inflammasome Complex	Nucleus Nucleoplasm Cytosol Inflammasome Complex NLRP1 Inflammasome Complex
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway	Protein Binding ATP Binding Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Domain Specific Binding
	Biological Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Substantia Nigra Development Regulation Of Inflammatory Response Cellular Response To Mechanical Stimulus Apoptotic Signaling Pathway	Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response Viral Process Response To Muramyl Dipeptide Defense Response To Bacterium Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Innate Immune Response Positive Regulation Of Interleukin-1 Beta Secretion Regulation Of Inflammatory Response Neuron Apoptotic Process NLRP1 Inflammasome Complex Assembly
Pathways			The NLRP1 inflammasome
Drugs
Diseases
GWAS			Migraine ( 27322543)
Interacting Genes		3 interacting genes: MAX NLRP1 PPHLN1	9 interacting genes: APAF1 BCL2 BCL2L1 CASP1 CASP2 CASP5 CASP9 NOD1 PYCARD
Entrez ID		838	22861
HPRD ID		04048	07364
Ensembl ID		ENSG00000137757	ENSG00000091592
Uniprot IDs		P51878	Q9C000
PDB IDs			1PN5 3KAT 4IFP 4IM6 5Y3S
Enriched GO Terms of Interacting Partners?
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