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ITCH and CYLD
Number of citations of the paper that reports this interaction (PubMedID
22057290
)
39
Data Source:
BioGRID
(pull down)
ITCH
CYLD
Description
itchy E3 ubiquitin protein ligase
CYLD lysine 63 deubiquitinase
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Early Endosome
Cytosol
Plasma Membrane
Membrane
Early Endosome Membrane
Protein-containing Complex
Intracellular Membrane-bounded Organelle
Extracellular Exosome
Centrosome
Spindle
Cytosol
Cytoplasmic Microtubule
Midbody
Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
Ciliary Basal Body
Perinuclear Region Of Cytoplasm
Ciliary Tip
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
Ribonucleoprotein Complex Binding
Ubiquitin-like Protein Ligase Binding
CXCR Chemokine Receptor Binding
Ubiquitin Protein Ligase Activity
Arrestin Family Protein Binding
Thiol-dependent Ubiquitin-specific Protease Activity
Protein Binding
Zinc Ion Binding
Protein Kinase Binding
Thiol-dependent Ubiquitinyl Hydrolase Activity
Lys63-specific Deubiquitinase Activity
Proline-rich Region Binding
Lys48-specific Deubiquitinase Activity
Biological Process
Protein Polyubiquitination
Regulation Of Cell Growth
Ubiquitin-dependent Protein Catabolic Process
Apoptotic Process
Inflammatory Response
Notch Signaling Pathway
Protein Ubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
Protein K29-linked Ubiquitination
Negative Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Innate Immune Response
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of JNK Cascade
Viral Entry Into Host Cell
Negative Regulation Of Defense Response To Virus
Defense Response To Virus
Protein Autoubiquitination
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Protein K63-linked Ubiquitination
Protein K48-linked Ubiquitination
Regulation Of Protein Deubiquitination
Regulation Of Hematopoietic Stem Cell Differentiation
Positive Regulation Of Receptor Catabolic Process
Ubiquitin-dependent Protein Catabolic Process
Cell Cycle
Regulation Of Mitotic Cell Cycle
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Wnt Signaling Pathway
Protein Deubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Negative Regulation Of Type I Interferon Production
CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment
Regulation Of Protein Binding
Innate Immune Response
Regulation Of B Cell Differentiation
Positive Regulation Of T Cell Differentiation
Negative Regulation Of JNK Cascade
Homeostasis Of Number Of Cells
Regulation Of Inflammatory Response
Positive Regulation Of T Cell Receptor Signaling Pathway
Regulation Of Necroptotic Process
Necroptotic Process
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Regulation Of Microtubule Cytoskeleton Organization
Protein K63-linked Deubiquitination
Protein K48-linked Deubiquitination
Negative Regulation Of Canonical Wnt Signaling Pathway
Ripoptosome Assembly Involved In Necroptotic Process
Negative Regulation Of NIK/NF-kappaB Signaling
Regulation Of Cilium Assembly
Negative Regulation Of P38MAPK Cascade
Positive Regulation Of Cellular Protein Localization
Protein Linear Deubiquitination
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Downregulation of ERBB4 signaling
NOD1/2 Signaling Pathway
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Degradation of GLI1 by the proteasome
Hedgehog 'on' state
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Negative regulators of DDX58/IFIH1 signaling
Antigen processing: Ubiquitination & Proteasome degradation
NOD1/2 Signaling Pathway
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ub-specific processing proteases
Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
Familial cylindromatosis
Multiple familial trichoepithelioma
Brooke-Spiegler syndrome
GWAS
Bipolar disorder (
31043756
)
Colorectal cancer or advanced adenoma (
30510241
)
Estimated glomerular filtration rate (
31152163
31015462
)
Heel bone mineral density (
28869591
)
Vitiligo (
27723757
)
Adventurousness (
30643258
)
Asthma (childhood onset) (
31036433
)
Asthma (time to onset) (
27130862
)
Body mass index (
28892062
)
Crohn's disease (
28067908
22412388
)
Femoral neck bone mineral density (
29499414
)
General risk tolerance (MTAG) (
30643258
)
Heel bone mineral density (
30598549
)
Inflammatory bowel disease (
28067908
)
Leprosy (
25642632
22019778
)
Lumbar spine bone mineral density (
29499414
22504420
)
Interacting Genes
103 interacting genes:
ARHGEF7
ARID1A
ARRB2
ARRDC3
ATN1
BECN1
BIN1
BRAF
CBL
CBLC
CDC34
CEP250
CPSF6
CPSF7
CSNK2A1
CXCR4
CYLD
DAZAP1
DTX1
DTX3L
ERBB4
EWSR1
FYN
GLIS3
GNAI2
HNRNPL
HNRNPUL1
JUN
JUNB
KPNB1
LAPTM5
LITAF
LRRK1
MAP2K4
MAPK8
MARVELD2
MLANA
N4BP1
NDFIP1
NDFIP2
NEDD9
NFE2
NOTCH1
NUDT21
NUMB
PABPC1
PACSIN1
POLR2A
POLR2B
POLR2C
POLR2E
POU5F1
PRKACA
RASSF5
RIPK1
RNF11
RPAP2
RPAP3
SCNN1A
SCNN1B
SF1
SGK3
SH3GL1
SH3GL2
SMAD2
SMAD3
SMARCC1
SMARCC2
SMARCE1
SMN1
SNX9
SPART
STAM2
SUFU
TAB1
TP63
TP73
TRPC4
TRPV1
TRPV4
TXNIP
UBAP2
UBAP2L
UBC
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2G1
UBE2J2
UBE2K
UBE2L3
UBE2M
UBE2O
UBE2Q1
UBE2Q2
UBE2R2
URI1
WBP2
22 interacting genes:
AKT1
AURKB
DDX58
DLG4
HDAC6
IKBKE
IKBKG
ITCH
MAP3K7
MAPRE1
MIB2
PTPA
TBK1
TP53
TRAF2
TRAF6
TRAF7
TRAIP
TRIM47
TUBA1A
UBC
UBE2S
Entrez ID
83737
1540
HPRD ID
07565
05427
Ensembl ID
ENSG00000078747
ENSG00000083799
Uniprot IDs
A0A590UJQ1
Q96J02
A0A024R6T1
Q9NQC7
PDB IDs
2DMV
2KYK
2NQ3
2P4R
2YSF
3TUG
4ROF
5C7M
5CQ2
5DWS
5DZD
5SXP
1IXD
1WHL
1WHM
2VHF
Enriched GO Terms of Interacting Partners
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