FERMT3 and TRIM15

Number of citations of the paper that reports this interaction (PubMedID 25450970)
15

Data Source:
BioGRID (protein complementation assay)

		FERMT3	TRIM15
Description		fermitin family member 3	tripartite motif containing 15
Image			No pdb structure
GO Annotations	Cellular Component	Podosome Extracellular Region Membrane Cell Junction Platelet Alpha Granule Lumen Cell Projection Extracellular Exosome
	Molecular Function	Integrin Binding	Protein Binding Zinc Ion Binding
	Biological Process	Platelet Degranulation Leukocyte Cell-cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Integrin Activation Regulation Of Cell-cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Platelet Aggregation	Mesodermal Cell Fate Determination Positive Regulation Of Type I Interferon Production Innate Immune Response Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Viral Release From Host Cell
Pathways		Platelet degranulation
Drugs
Diseases		Leukocyte adhesion deficiency (LAD), including the following four diseases: Leukocyte adhesion deficiency (I); Leukocyte adhesion deficiency (II); Leukocyte adhesion deficiency (III); LAD with Rac2 deficiency
GWAS		Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401)	Anger ( 24489884) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Neurociticism ( 29500382) Neuroticism ( 29255261)
Interacting Genes		9 interacting genes: APP EXOSC10 ILK ITGB1 LIMS1 LSM8 PARVA TINF2 TRIM15	36 interacting genes: ACD ACTB AXIN1 CFL1 CORO1B CTTN EHMT1 FAM151B FAM161A FBLIM1 FERMT2 FERMT3 GAB1 GTF2E1 IRF5 KEAP1 MED7 MSN MYBL2 NEXN PFN1 PRNP PTK2 PXN RABGEF1 ROCK1 SHC1 SNW1 SYK TAF9B TINF2 TRIM8 UBE2U VASP VCL VIM
Entrez ID		83706	89870
HPRD ID		07440	15551
Ensembl ID		ENSG00000149781	ENSG00000204610
Uniprot IDs		Q86UX7	Q5SRL0 Q9C019
PDB IDs		2YS3
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
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