FZD6 and WNT4

Number of citations of the paper that reports this interaction (PubMedID 15265686)
59

Data Source:
HPRD (in vivo)

		FZD6	WNT4
Description		frizzled class receptor 6	Wnt family member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Integral Component Of Membrane Apical Plasma Membrane Apicolateral Plasma Membrane Cytoplasmic Vesicle Membrane	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Amyloid-beta Binding G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding Ubiquitin Protein Ligase Binding Wnt-activated Receptor Activity	Transcription Corepressor Activity Frizzled Binding Receptor Ligand Activity
	Biological Process	Neural Tube Closure Hair Follicle Development G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Platelet Activation Cell Proliferation In Midbrain Non-canonical Wnt Signaling Pathway Embryonic Nail Plate Morphogenesis Inner Ear Morphogenesis Negative Regulation Of DNA-binding Transcription Factor Activity Establishment Of Body Hair Planar Orientation Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Midbrain Morphogenesis	Branching Involved In Ureteric Bud Morphogenesis Kidney Development Epithelial To Mesenchymal Transition Embryonic Epithelial Tube Formation Liver Development Male Gonad Development Female Gonad Development Cellular Response To Starvation Negative Regulation Of Gene Expression Negative Regulation Of Steroid Biosynthetic Process Wnt Signaling Pathway Regulation Of Cell-cell Adhesion Neuron Differentiation Female Sex Determination Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process Immature T Cell Proliferation In Thymus Non-canonical Wnt Signaling Pathway Via MAPK Cascade Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Hormone Metabolic Process Positive Regulation Of GTPase Activity Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Oocyte Development Smooth Muscle Cell Differentiation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Mesenchymal To Epithelial Transition Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Negative Regulation Of Wound Healing Mammary Gland Epithelium Development Positive Regulation Of Dermatome Development Paramesonephric Duct Development Negative Regulation Of Testicular Blood Vessel Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Renal Vesicle Formation Renal Vesicle Induction Metanephric Mesenchymal Cell Differentiation Metanephric Tubule Formation Metanephric Nephron Morphogenesis Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway PCP/CE pathway PCP/CE pathway Regulation of FZD by ubiquitination RNF mutants show enhanced WNT signaling and proliferation	TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists PCP/CE pathway PCP/CE pathway
Drugs
Diseases			46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Triglyceride levels x loop diuretics use interaction ( 31806883)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Birth weight ( 31043758 27680694) Bone mineral density (paediatric, lower limb) ( 24945404) Bone mineral density (paediatric, skull) ( 24945404) Bone mineral density (paediatric, total body less head) ( 28743860 24945404) Bone mineral density (paediatric, upper limb) ( 24945404) Bone mineral density (total hip) ( 29883787) Colorectal cancer ( 25990418) Daytime sleep phenotypes ( 27126917) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Dupuytren's disease ( 28886342 21732829) Endometriosis ( 23104006 23472165 20601957 28333195 28537267) Epithelial ovarian cancer ( 25581431) Extremely high intelligence ( 29520040) Gestational age at birth (maternal effect) ( 28877031) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Hip circumference adjusted for BMI ( 25673412) Lumbar spine bone mineral density ( 22504420) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Right-sided colonic diverticulosis ( 31089239) Spine bone size ( 31053729) Systolic blood pressure ( 30224653) TB-LM or TBLH-BMD (pleiotropy) ( 28743860) Uterine fibroids ( 31249589 30194396 31649266)
Interacting Genes		2 interacting genes: SFRP1 WNT4	8 interacting genes: APP FZD6 LGALS3BP P2RX4 PORCN SFRP1 SFRP2 TMEM80
Entrez ID		8323	54361
HPRD ID		04559	04601
Ensembl ID		ENSG00000164930	ENSG00000162552
Uniprot IDs		A0A024R9E9 B4DL33 B4E236 O60353	P56705
PDB IDs
Enriched GO Terms of Interacting Partners?
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