CAPN3 and DYSF

Number of citations of the paper that reports this interaction (PubMedID 15827562)
24

Data Source:
HPRD (in vivo)

		CAPN3	DYSF
Description		calpain 3	dysferlin
Image
GO Annotations	Cellular Component	Intracellular Cell Nucleus Cytoplasm Cytosol Plasma Membrane Myofibril Z Disc T-tubule Protein-containing Complex	Nucleus Endosome Early Endosome Late Endosome Golgi Apparatus Microtubule Plasma Membrane Integral Component Of Membrane Lamellipodium Endocytic Vesicle T-tubule Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Centriolar Satellite Sarcolemma Extracellular Exosome Membrane Microdomain
	Molecular Function	Catalytic Activity Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Structural Constituent Of Muscle Sodium Ion Binding Titin Binding Ligase Regulator Activity Molecular Adaptor Activity	Calcium Ion Binding Protein Binding Phospholipid Binding Calcium-dependent Phospholipid Binding Microtubule Binding Alpha-tubulin Binding
	Biological Process	Proteolysis Apoptotic Process Muscle Organ Development Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Response To Muscle Activity Protein Catabolic Process Myofibril Assembly Protein Destabilization Negative Regulation Of Protein Sumoylation Negative Regulation Of Apoptotic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Sarcomere Organization Regulation Of Myoblast Differentiation Positive Regulation Of Proteolysis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Regulation Of Catalytic Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Muscle Structure Development Protein-containing Complex Assembly G1 To G0 Transition Involved In Cell Differentiation Cellular Response To Calcium Ion Cellular Response To Salt Stress Protein Localization To Membrane Self Proteolysis Calcium-dependent Self Proteolysis	Angiogenesis Plasma Membrane Repair Positive Regulation Of Endothelial Cell Proliferation Monocyte Activation Involved In Immune Response Macrophage Activation Involved In Immune Response Glycerol Metabolic Process Vesicle Fusion Muscle Contraction Plasma Membrane Organization Negative Regulation Of Gene Expression Lipid Storage T-tubule Organization Negative Regulation Of Protein Catabolic Process Skeletal Muscle Tissue Regeneration Fat Cell Differentiation Positive Regulation Of Cell Adhesion Muscle Fiber Development Cytokine Secretion Negative Regulation Of Phagocytosis Membrane Fusion Cellular Response To Osmotic Stress Positive Regulation Of Neutrophil Chemotaxis Regulation Of Calcium Ion Import Negative Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Protein Polyubiquitination
Pathways		Degradation of the extracellular matrix	Smooth Muscle Contraction Smooth Muscle Contraction
Drugs
Diseases		Calpainopathy; Limb-girdle muscular dystrophy 2A (LGMD2A) Limb-girdle muscular dystrophy (LGMD)	Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Dysferlinopathies, including: Miyoshi myopathy (MM); Limb-girdle muscular dystrophy (LGMD) 2B; Distal myopathy with anterior tibial onset (DMAT) Limb-girdle muscular dystrophy (LGMD)
GWAS		Fibrinogen levels ( 28107422 26561523) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Triglyceride levels ( 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 24097068 25961943 20686565)	Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Hip circumference adjusted for BMI ( 28552196) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) PR interval in Tripanosoma cruzi seropositivity ( 24324551) Protein quantitative trait loci ( 18464913) Urate levels in overweight individuals ( 25811787)
Interacting Genes		9 interacting genes: CEP76 DYSF FLNC NECAB2 NTAQ1 OSGIN1 TFCP2 TTN YWHAQ	4 interacting genes: ANXA1 ANXA2 CAPN3 CAV3
Entrez ID		825	8291
HPRD ID		00255	04307
Ensembl ID		ENSG00000092529	ENSG00000135636
Uniprot IDs		A0A0S2Z3E1 P20807	O75923
PDB IDs		1Y9V 4OKH 6BDT 6BGP 6BJD 6BKJ	4CAH 4CAI 4IHB 4IQH
Enriched GO Terms of Interacting Partners?
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