DOCK8 and FAM161A

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		DOCK8	FAM161A
Description		dedicator of cytokinesis 8	FAM161 centrosomal protein A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Leading Edge Membrane Lamellipodium Membrane	Astral Microtubule Photoreceptor Inner Segment Centrosome Spindle Microtubule Cilium Photoreceptor Connecting Cilium Ciliary Basal Body Mitotic Spindle Mitotic Spindle Pole
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	Protein Binding Microtubule Binding Identical Protein Binding
	Biological Process	Immunological Synapse Formation Small GTPase Mediated Signal Transduction Blood Coagulation Dendritic Cell Migration Positive Regulation Of GTPase Activity Memory T Cell Proliferation Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Establishment Of T Cell Polarity Cellular Response To Chemokine Positive Regulation Of T Cell Migration	Visual Perception Cilium Organization Response To Stimulus Cilium Assembly Positive Regulation Of Protein Acetylation
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Non-syndromic autosomal dominant mental retardation	Retinitis pigmentosa (RP)
GWAS		Blond vs. brown/black hair color ( 30531825) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Mean platelet volume ( 22139419 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Obesity-related traits ( 23251661) Platelet count ( 27863252) Platelet distribution width ( 27863252) Post bronchodilator FEV1 ( 26634245) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 27863252)	Atrial fibrillation ( 29892015) Erectile dysfunction ( 30583798) Systemic lupus erythematosus ( 28714469)
Interacting Genes		24 interacting genes: BYSL CARHSP1 CDC42 CHMP2A DGCR6 EXOSC5 FAM124A FAM161A FANCL FBXL12 HBZ KRT40 MED30 MEOX2 MRPL38 MTG1 PIMREG RAC1 RHOJ RHOQ RTP5 SMAD2 ZFC3H1 ZNF581	66 interacting genes: BEND3 BEND5 BRCA1 CADPS CALCOCO1 CALCOCO2 CARD9 CBY2 CCDC102B CCDC136 CCDC33 CCDC57 CCNDBP1 CDR2 CEP44 CEP57L1 CEP63 CEP70 DHX32 DOCK8 DVL2 EHMT2 FAM9B FSD2 GOLGA2 HMBOX1 IKZF1 KASH5 KIAA0753 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP5-9 LMNA LZTS2 MCM6 MDFI MID2 MIPOL1 MTUS2 NECAB2 NINL NUTM1 PDE4DIP PHC2 PNMA2 PPFIA1 PPM1F RINT1 RUNDC3A SSX2IP STX11 SYCE1 TFIP11 TMCC2 TNIP1 TRAF1 TRIM15 TRIM37 TRIM54 TSGA10 TXLNB ZBTB1 ZBTB14 ZBTB43 ZBTB8A
Entrez ID		81704	84140
HPRD ID		10920	18996
Ensembl ID		ENSG00000107099	ENSG00000170264
Uniprot IDs		E2J6M5 E2J6M6 Q8NF50	Q3B820
PDB IDs
Enriched GO Terms of Interacting Partners?
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