NECTIN4 and PICK1

Number of citations of the paper that reports this interaction (PubMedID 15811349)
11

Data Source:
HPRD (two hybrid)

		NECTIN4	PICK1
Description		nectin cell adhesion molecule 4	protein interacting with PRKCA 1
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GO Annotations	Cellular Component	Plasma Membrane Adherens Junction Integral Component Of Membrane Extracellular Exosome	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Synaptic Vesicle Postsynaptic Density Aggresome Cell Junction Endocytic Vesicle Membrane Trans-Golgi Network Membrane Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Postsynaptic Early Endosome
	Molecular Function	Virus Receptor Activity Protein Binding Signaling Receptor Activity Identical Protein Binding Protein Homodimerization Activity Cell Adhesion Molecule Binding	G Protein-coupled Receptor Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Phospholipid Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding Arp2/3 Complex Binding Membrane Curvature Sensor Activity
	Biological Process	Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Adherens Junction Organization Viral Entry Into Host Cell	Positive Regulation Of Receptor Internalization Protein Phosphorylation Intracellular Protein Transport Retrograde Vesicle-mediated Transport, Golgi To ER Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Monoamine Transport Glial Cell Development Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Cellular Response To Decreased Oxygen Levels Cellular Response To Glucose Starvation DNA Methylation Involved In Embryo Development DNA Methylation Involved In Gamete Generation Receptor Clustering Neuronal Ion Channel Clustering Regulation Of Insulin Secretion Long-term Synaptic Depression Dendritic Spine Organization Dendritic Spine Maintenance
Pathways		Adherens junctions interactions Nectin/Necl trans heterodimerization	Cell surface interactions at the vascular wall Trafficking of GluR2-containing AMPA receptors
Drugs
Diseases		Ectodermal dysplasia-syndactyly syndrome (EDSS)
GWAS			Body fat percentage ( 26833246)
Interacting Genes		5 interacting genes: AFDN NECTIN1 NECTIN2 PICK1 TIGIT	47 interacting genes: AFDN AKT1 APTX AQP1 ARF1 ARF3 ASIC1 ASIC2 ATXN1L ATXN3 ATXN7 ATXN7L3 BTG2 CIC COIL CTNNB1 EFNB1 EFNB2 EHD2 EPHB2 ERBB2 ERBIN F11R FXN GFI1 GFI1B GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRIP1 GRM3 GRM7 JAM3 LRP2BP NECTIN2 NECTIN4 PRKCA PRKCG PRKN PRLHR SACS SLC6A3 UBQLN4 USP7
Entrez ID		81607	9463
HPRD ID		17934	16176
Ensembl ID		ENSG00000143217	ENSG00000100151
Uniprot IDs		K4PZ75 Q96NY8	A0A024R1J5 Q9NRD5
PDB IDs		4FRW 4GJT 4JJH	2GZV 6AR4 6BJN 6BJO
Enriched GO Terms of Interacting Partners?
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