WNT5B and PORCN

Number of citations of the paper that reports this interaction (PubMedID 10866835)
33

Data Source:
HPRD (in vivo, in vitro)

		WNT5B	PORCN
Description		Wnt family member 5B	porcupine O-acyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse
	Molecular Function	Signaling Receptor Binding Frizzled Binding	Wnt-protein Binding Palmitoleoyltransferase Activity
	Biological Process	Chondrocyte Differentiation Wnt Signaling Pathway Neuron Differentiation Positive Regulation Of Cell Migration Wound Healing Cell Fate Commitment Fat Cell Differentiation Positive Regulation Of Fat Cell Differentiation Lens Fiber Cell Development Cellular Response To Retinoic Acid Negative Regulation Of Canonical Wnt Signaling Pathway	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Protein Palmitoleylation Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking PCP/CE pathway PCP/CE pathway	WNT ligand biogenesis and trafficking WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
Drugs
Diseases			Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS		Gout ( 22179738) Sulfasalazine-induced agranulocytosis ( 28762467)
Interacting Genes		2 interacting genes: APPBP2 PORCN	6 interacting genes: WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B
Entrez ID		81029	64840
HPRD ID		05899	06680
Ensembl ID		ENSG00000111186	ENSG00000102312
Uniprot IDs		Q9H1J7	Q9H237
PDB IDs
Enriched GO Terms of Interacting Partners?
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