ALX1 and ALX4

Number of citations of the paper that reports this interaction (PubMedID 9847249)
31

Data Source:
HPRD (in vitro)

		ALX1	ALX4
Description		ALX homeobox 1	ALX homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Golgi Apparatus Nuclear Body	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Protein Homodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cartilage Condensation Neural Crest Cell Migration Neural Tube Closure Transcription By RNA Polymerase II Multicellular Organism Development Anterior/posterior Pattern Specification Positive Regulation Of Epithelial To Mesenchymal Transition Embryonic Limb Morphogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis Roof Of Mouth Development	Skeletal System Development Hair Follicle Development Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Embryonic Skeletal System Morphogenesis Roof Of Mouth Development
Pathways
Drugs
Diseases		Frontonasal dysplasia	Frontonasal dysplasia Enlarged parietal foramina/cranium bifidum
GWAS		Bone mineral density (Ward's triangle area) ( 27397699) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Nonsyndromic cleft lip ( 31609978) Nose size ( 27182965)	Blood pressure measurement (high sodium intervention) ( 24165912) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) Gout ( 22179738) Male-pattern baldness ( 29146897 27182965) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		5 interacting genes: ALX4 CREBBP EP300 IPO13 SRA1	12 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2
Entrez ID		8092	60529
HPRD ID		03316	05661
Ensembl ID		ENSG00000180318	ENSG00000052850
Uniprot IDs		Q15699 V9HWA7	Q9H161
PDB IDs			2M0C
Enriched GO Terms of Interacting Partners?
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