HMGA2 and NPM1

Number of citations of the paper that reports this interaction (PubMedID 16293633)
31

Data Source:
BioGRID (far western blotting, far western blotting)

		HMGA2	NPM1
Description		high mobility group AT-hook 2	nucleophosmin 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome Nucleus Nucleoplasm Protein-DNA Complex Senescence-associated Heterochromatin Focus SMAD Protein Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Focal Adhesion Membrane Spindle Pole Centrosome Protein-containing Complex Protein-DNA Complex Ribonucleoprotein Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding AT DNA Binding Transcription Coregulator Activity DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Protein Binding Transcription Factor Binding DNA Binding, Bending Nucleosomal DNA Binding CAMP Response Element Binding MH2 Domain Binding MH1 Domain Binding Transcription Regulatory Region DNA Binding SMAD Binding 5'-deoxyribose-5-phosphate Lyase Activity C2H2 Zinc Finger Domain Binding	Core Promoter Binding Chromatin Binding Transcription Coactivator Activity RNA Binding Protein Kinase Inhibitor Activity Protein Binding Transcription Factor Binding Protein Kinase Binding Tat Protein Binding Activating Transcription Factor Binding Histone Binding Protein Homodimerization Activity Ribosomal Large Subunit Binding Ribosomal Small Subunit Binding NF-kappaB Binding Unfolded Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Epithelial To Mesenchymal Transition Chondrocyte Differentiation Mesodermal-endodermal Cell Signaling Base-excision Repair Chromatin Organization Regulation Of Transcription, DNA-templated Mitotic G2 DNA Damage Checkpoint Multicellular Organism Development Response To Virus Regulation Of Cell Cycle Process Positive Regulation Of Gene Expression Chromosome Condensation Chromosome Breakage Heterochromatin Assembly Histone H2A-S139 Phosphorylation Senescence-associated Heterochromatin Focus Assembly Endodermal Cell Differentiation Chondrocyte Proliferation Regulation Of Growth DNA Damage Response, Detection Of DNA Damage Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of DNA Binding Negative Regulation By Host Of Viral Transcription Fat Cell Differentiation Positive Regulation Of Angiogenesis Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesodermal Cell Differentiation Mesenchymal Cell Differentiation Stem Cell Differentiation Cell Division Positive Regulation Of Cell Cycle Arrest Positive Regulation Of Cell Proliferation In Bone Marrow Positive Regulation Of Protein Serine/threonine Kinase Activity Oncogene-induced Cell Senescence Regulation Of Stem Cell Population Maintenance Positive Regulation Of Stem Cell Proliferation Positive Regulation Of Transcription Regulatory Region DNA Binding Positive Regulation Of Cellular Response To X-ray Negative Regulation Of Cellular Senescence Positive Regulation Of Cellular Senescence Positive Regulation Of Response To DNA Damage Stimulus Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining Regulation Of Cellular Response To Drug	Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus DNA Repair Nucleosome Assembly Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II RRNA Export From Nucleus Intracellular Protein Transport Nucleocytoplasmic Transport Centrosome Cycle Signal Transduction Cell Aging Protein Localization Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Centrosome Duplication Negative Regulation Of Centrosome Duplication Viral Process Regulation Of Endodeoxyribonuclease Activity CENP-A Containing Nucleosome Assembly Cellular Response To UV Ribosome Assembly Ribosomal Large Subunit Biogenesis Ribosomal Small Subunit Biogenesis Negative Regulation Of Apoptotic Process Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centriole Replication Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Endoribonuclease Activity Regulation Of EIF2 Alpha Phosphorylation By DsRNA Regulation Of MRNA Stability Involved In Cellular Response To UV Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)	Nuclear import of Rev protein Nuclear import of Rev protein SUMOylation of transcription cofactors Deposition of new CENPA-containing nucleosomes at the centromere TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs			Artenimol
Diseases
GWAS		Adverse response to drug ( 30420678) Aortic root size ( 19584346) Axial length ( 24144296) Birth length ( 25281659) Birth weight ( 23202124 31043758 27680694) Brain structure ( 22504417) Chin dimples ( 27182965) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Head circumference (infant) ( 22504419) Heart rate response to exercise ( 29769521) Heel bone mineral density ( 30598549) Height ( 21998595 28552196 20881960 22021425 25282103 25429064 19343178 23563607 31562340 18391950 18391951 18391952 20397748 17767157) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 25673412) Infant length ( 25281659) Late-onset Alzheimer's disease ( 27770636) Medication use (drugs used in diabetes) ( 31015401) Offspring birth weight ( 31043758) Permanent tooth development ( 21931568) Polycystic ovary syndrome ( 22885925) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes ( 22885922 24509480 30054458 26961502 29358691 25102180 30297969 20581827 28869590) Type 2 diabetes nephropathy ( 21150874) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412)	Height ( 28552196)
Interacting Genes		21 interacting genes: APEX1 CDK1 CSNK2A1 CSNK2A2 E4F1 MDM2 NFKB1 NPM1 PA2G4 PCBP2 PIAS3 PRKCA PRMT6 PSIP1 PTBP1 RB1 RELA SMAD3 SYNCRIP TP53 XRCC6	59 interacting genes: ABCC1 ACY1 ALK APP ARF1 CD24 CDK1 CDK2 CDKN2A CDT1 CENPW CLK1 COX8A CSNK2A1 EIF2AK2 ELF4 EP300 ERG ESR1 FBXW7 GADD45A GNAI2 GNL3 GRB2 GZMM H2AC20 H2BC21 H3-4 HAND2 HMGA1 HMGA2 HOXA7 IRF1 IRS1 MDM2 NCL NOP2 NPM2 PADI4 PARP1 PLCG1 PLCG2 PLK1 PSMC4 RELA RPGR SENP3 SHC1 SIL1 SP1 SREK1 TCERG1 TFAP2A TP53 TRIM28 UBC UQCRH XPO1 YY1
Entrez ID		8091	4869
HPRD ID		02827	01246
Ensembl ID		ENSG00000149948	ENSG00000181163
Uniprot IDs		F5H2A4 F5H6H0 P52926 Q1M183	A0A0S2Z491 A0A0S2Z4G7 A0A140VJQ2 P06748
PDB IDs			2LLH 2P1B 2VXD 5EHD
Enriched GO Terms of Interacting Partners?
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