YEATS4 and RNF8

Number of citations of the paper that reports this interaction (PubMedID 22068108)
3

Data Source:
BioGRID (two hybrid)

		YEATS4	RNF8
Description		YEATS domain containing 4	ring finger protein 8
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GO Annotations	Cellular Component	Nucleoplasm Nuclear Matrix Nuclear Membrane NuA4 Histone Acetyltransferase Complex	Ubiquitin Ligase Complex Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Midbody Site Of Double-strand Break
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding	Chromatin Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ubiquitin Protein Ligase Binding Histone Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Binding Ubiquitin Protein Ligase Activity
	Biological Process	Mitotic Cell Cycle Cytoskeleton Organization Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Ubiquitin-dependent Protein Catabolic Process Cellular Response To DNA Damage Stimulus Cell Cycle Spermatid Development Response To Ionizing Radiation Viral Process Protein Ubiquitination Histone H2A Ubiquitination Histone H2B Ubiquitination Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Spermatogenesis, Exchange Of Chromosomal Proteins Interstrand Cross-link Repair Histone Exchange Isotype Switching Positive Regulation Of DNA Repair Cell Division Protein Autoubiquitination Protein K63-linked Ubiquitination Histone H2A K63-linked Ubiquitination Protein K48-linked Ubiquitination
Pathways		HATs acetylate histones Activation of the TFAP2 (AP-2) family of transcription factors	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Complete remission in asthma ( 29786918) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Height ( 31562340 18391951) Metabolite levels ( 23823483) Response to antidepressants (symptom remission) ( 29160301) Response to diuretic therapy ( 18591461) Response to SSRI in MDD or conscientiouness ( 29559929)	Acne (severe) ( 24927181) Restless legs syndrome ( 29029846)
Interacting Genes		13 interacting genes: CEP162 FRMD4A H3C1 MLLT10 MRGBP MYCN NUMA1 PFDN1 RNF8 SMARCB1 TACC1 TACC2 TFAP2B	41 interacting genes: BLM CCDC85B CEP44 CHD4 CHEK2 EXOSC2 H2AC20 H2AX H2BC21 H2BC3 H3-3B HOMEZ JMJD1C KDM4A MAD1L1 MAGED1 MDC1 MDM2 PCNA PNMA2 POLD4 RBFOX2 RXRA RYBP SEPTIN3 SUMO2 SUMO3 TMEM79 TRIM29 UBC UBE2D1 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V2 UBE2W VCP WASL YEATS4
Entrez ID		8089	9025
HPRD ID		03666	11521
Ensembl ID		ENSG00000127337	ENSG00000112130
Uniprot IDs		F8W0J4 O95619	O76064
PDB IDs		5VNA 5VNB 5XTZ 5Y8V	2CSW 2PIE 4AYC 4ORH 4WHV
Enriched GO Terms of Interacting Partners?
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