DUSP16 and MAPK9

Number of citations of the paper that reports this interaction (PubMedID 11359773)
43

Data Source:
HPRD (in vivo, in vitro)

		DUSP16	MAPK9
Description		dual specificity phosphatase 16	mitogen-activated protein kinase 9
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Vesicle	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol
	Molecular Function	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity	JUN Kinase Activity MAP Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding
	Biological Process	Inactivation Of MAPK Activity Dephosphorylation Peptidyl-tyrosine Dephosphorylation MAPK Export From Nucleus MAPK Phosphatase Export From Nucleus, Leptomycin B Sensitive	Protein Phosphorylation JNK Cascade JUN Phosphorylation Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Peptidyl-serine Phosphorylation Positive Regulation Of Protein Ubiquitination Cellular Response To Reactive Oxygen Species Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Circadian Rhythm Rhythmic Process Regulation Of DNA-binding Transcription Factor Activity Protein Localization To Tricellular Tight Junction Cellular Response To Cadmium Ion Positive Regulation Of Podosome Assembly Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway
Pathways		RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Suppression of autophagy	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors
Drugs			N-{3-[5-(1H-1,2,4-triazol-3-yl)-1H-indazol-3-yl]phenyl}furan-2-carboxamide
Diseases
GWAS		Height ( 31562340) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 30578418)	Blood protein levels ( 30072576)
Interacting Genes		9 interacting genes: ERBB4 MAPK1 MAPK10 MAPK11 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9	77 interacting genes: ACP5 AKT1 ARRB1 ARRB2 ATF2 ATF7 BCL2L1 BCL2L11 C1orf94 CASP3 CCDC33 CDC25B CDC25C CEP126 CEP44 CLU CTBP1 CTNNB1 CYHR1 DUSP16 DUSP19 DUSP4 EEF2K EFHC2 EGFR ELK1 ELK3 FBXO7 GRB2 H3-3A HDAC9 HSF1 IRS1 JDP2 JUN JUNB JUND L3MBTL3 LMAN2 LNX1 LNX2 MACF1 MAP2K4 MAP2K7 MAP3K1 MAP3K10 MAPK8IP1 MAPK8IP2 MAPK8IP3 MAPKAPK5 MAPKBP1 MAPT MEOX1 NCF1 NCSTN NFATC3 NFATC4 PRKD1 PSEN1 RB1 RPS6KB1 SF3B4 SH3BP5 SHMT1 SMAD2 SMAD3 SMCO3 SSU72 TEX11 TOB1 TP53 TRAF2 TUSC2 WDR62 XPNPEP1 XPO7 ZBTB25
Entrez ID		80824	5601
HPRD ID		09525	04206
Ensembl ID		ENSG00000111266	ENSG00000050748
Uniprot IDs		A0A024RAR2 Q9BY84	D7R525 D7R526 P45984
PDB IDs		2VSW 3TG3 4YR8	3E7O 3NPC
Enriched GO Terms of Interacting Partners?
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