DNAJC5 and SLC17A8

Number of citations of the paper that reports this interaction (PubMedID 29997244)
3

Data Source:
BioGRID (fluorescent resonance energy transfer, affinity chromatography technology)

		DNAJC5	SLC17A8
Description		DnaJ heat shock protein family (Hsp40) member C5	solute carrier family 17 member 8
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Lysosomal Membrane Plasma Membrane Membrane Neuromuscular Junction Azurophil Granule Membrane Specific Granule Membrane Melanosome Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Anchored Component Of Synaptic Vesicle Membrane	Multivesicular Body Integral Component Of Membrane Cell Junction Integral Component Of Synaptic Vesicle Membrane Synaptic Vesicle Membrane Perikaryon Axon Terminus Excitatory Synapse Apical Dendrite Basal Dendrite Glial Limiting End-foot Pericellular Basket
	Molecular Function	Protein Binding ATP-dependent Protein Binding	L-glutamate Transmembrane Transporter Activity Neurotransmitter Transporter Activity Symporter Activity Transmembrane Transporter Activity
	Biological Process	Exocytosis Neurotransmitter Secretion Synaptic Vesicle Exocytosis Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Regulated Exocytosis Chaperone-mediated Protein Folding Regulation Of Synaptic Vesicle Cycle	Neural Retina Development Ion Transport Sodium Ion Transport Anion Transport Brain Development Sensory Perception Of Sound L-glutamate Transmembrane Transport Synaptic Transmission, Glutamatergic Regulation Of Synapse Structure Or Activity Cochlea Development Neurotransmitter Loading Into Synaptic Vesicle
Pathways		Neutrophil degranulation GABA synthesis, release, reuptake and degradation	Organic anion transporters Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)
Drugs
Diseases
GWAS		Prostate cancer ( 23535732)	Squamous cell carcinoma ( 23341777)
Interacting Genes		56 interacting genes: AGFG1 AP2B1 ARHGEF15 BTC CADM1 CADPS CASK CD2 CFTR CGB5 CLCN3 EFNB1 ERC1 FAS FCHO1 GRM8 HBA2 HGS KHDC4 LIN7A LIN7C NECAP1 NRXN3 NUMB PPFIA1 PPFIA4 PRKACA PRKCG PRRC2B PSMD12 RABGEF1 RBSN SCAMP1 SCAMP3 SCAMP5 SH3GL3 SLC17A8 SLC18A2 SLC30A3 SLC32A1 SNAP29 SNAP91 SNCA STX12 STX3 STX4 STX6 STX7 SV2A SYT12 SYT5 SYT9 VAMP1 VAMP3 VAMP4 VAMP7	1 interacting genes: DNAJC5
Entrez ID		80331	246213
HPRD ID		08539	10457
Ensembl ID		ENSG00000101152	ENSG00000179520
Uniprot IDs		Q6AHX3 Q9H3Z4	Q8NDX2
PDB IDs		2N04 2N05
Enriched GO Terms of Interacting Partners?
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