PTGES2 and CRY2

		PTGES2	CRY2
Description		prostaglandin E synthase 2	cryptochrome circadian regulator 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cell Nucleus Mitochondrion Cytosol Integral Component Of Membrane Azurophil Granule Lumen Perinuclear Region Of Cytoplasm	Extracellular Region Nucleus Cytosol Nuclear Speck
	Molecular Function	DNA Binding Protein Binding Electron Transfer Activity Protein Disulfide Oxidoreductase Activity Lyase Activity Heme Binding Glutathione Binding Prostaglandin-E Synthase Activity	Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding Single-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Blue Light Photoreceptor Activity Phosphatase Binding FAD Binding
	Biological Process	Cyclooxygenase Pathway Electron Transport Chain Neutrophil Degranulation Cell Redox Homeostasis Positive Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Photoreactive Repair Circadian Rhythm Response To Light Stimulus Blue Light Signaling Pathway Response To Activity Protein-chromophore Linkage Negative Regulation Of Phosphoprotein Phosphatase Activity Circadian Regulation Of Gene Expression Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Transcription, DNA-templated Regulation Of Sodium-dependent Phosphate Transport Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Neutrophil degranulation	Circadian Clock
Drugs
Diseases		Penile cancer
GWAS		Body mass index ( 26426971)	Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Axial length ( 24144296) Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Glycemic traits (pleiotropy) ( 31021400) Type 2 diabetes ( 30297969) Visceral fat ( 22589738)
Interacting Genes		8 interacting genes: C1orf189 C9orf78 CEBPB COL23A1 CRY2 EXOSC10 PTGFR RPL27A	22 interacting genes: ATXN1 BHLHE41 BRCA1 CLOCK CTBP1 DELEC1 EZH2 LMNA MTUS2 NPAS2 PDE9A PER1 PER2 PER3 PPP2R1B PPP2R5D PPP2R5E PPP5C PTGES2 STK11 TIMELESS TTC1
Entrez ID		80142	1408
HPRD ID		07458	07226
Ensembl ID		ENSG00000148334	ENSG00000121671
Uniprot IDs		A6NHH0 B3KPZ2 B4DWP1 Q9H7Z7	A0A0D2X7Z3 A2I2P1 Q49AN0
PDB IDs
Enriched GO Terms of Interacting Partners?
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