Wiki-CORONA
About
Search
Browse
Data Sources
People
Funding
Advanced Search
HPS6 and PIK3CB
Number of citations of the paper that reports this interaction (PubMedID
21900206
)
114
Data Source:
BioGRID
(two hybrid)
HPS6
PIK3CB
Description
HPS6 biogenesis of lysosomal organelles complex 2 subunit 3
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Lysosomal Membrane
Endoplasmic Reticulum
Membrane
BLOC-2 Complex
Early Endosome Membrane
Nucleoplasm
Nucleolus
Cytoplasm
Cytosol
Plasma Membrane
Phosphatidylinositol 3-kinase Complex
Membrane
Midbody
Intracellular Membrane-bounded Organelle
Molecular Function
Protein Binding
Rab GTPase Binding
GTP-dependent Protein Binding
Protein Binding
ATP Binding
Kinase Activity
1-phosphatidylinositol-3-kinase Activity
Phosphatidylinositol 3-kinase Activity
1-phosphatidylinositol-4-phosphate 3-kinase Activity
Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
Phosphatidylinositol Kinase Activity
Phosphatidylinositol-3,4-bisphosphate 5-kinase Activity
Biological Process
Organelle Organization
Blood Coagulation
Melanocyte Differentiation
Lysosome Localization
Protein Localization To Membrane
Activation Of MAPK Activity
Regulation Of Cell-matrix Adhesion
Phosphatidylinositol Biosynthetic Process
Endocytosis
Autophagy
Chemotaxis
Signal Transduction
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
G Protein-coupled Receptor Signaling Pathway
Axon Guidance
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Phosphatidylinositol 3-kinase Signaling
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Phosphorylation
Cell Migration
Cytokine-mediated Signaling Pathway
Platelet Activation
Positive Regulation Of Neutrophil Apoptotic Process
Phosphatidylinositol-3-phosphate Biosynthetic Process
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Phosphatidylinositol Phosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Phosphatidylinositol-mediated Signaling
T Cell Receptor Signaling Pathway
Leukocyte Migration
Positive Regulation Of Protein Kinase B Signaling
Platelet Aggregation
Regulation Of Clathrin-dependent Endocytosis
Pathways
PI3K Cascade
IRS-mediated signalling
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Synthesis of PIPs at the plasma membrane
Downstream signal transduction
PI3K/AKT activation
Downstream TCR signaling
Role of phospholipids in phagocytosis
Tie2 Signaling
Constitutive Signaling by Aberrant PI3K in Cancer
DAP12 signaling
Role of LAT2/NTAL/LAB on calcium mobilization
Nephrin family interactions
VEGFA-VEGFR2 Pathway
VEGFA-VEGFR2 Pathway
Interleukin-3, Interleukin-5 and GM-CSF signaling
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K)
Interleukin receptor SHC signaling
Regulation of signaling by CBL
Regulation of signaling by CBL
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Drugs
Caffeine
XL765
Diseases
Hermansky-Pudlak syndrome (HPS)
GWAS
Household income (MTAG) (
31844048
)
Intelligence (MTAG) (
29326435
)
Male-pattern baldness (
28196072
)
Interacting Genes
9 interacting genes:
CREB1
EP300
HPS5
MARK4
MNAT1
OSGEP
PIK3CB
PUM3
TTC19
11 interacting genes:
AGTR2
ALAS1
DVL3
HCK
HPS6
MME
PIK3R1
PRKCD
PRKCE
RAB5B
YWHAQ
Entrez ID
79803
5291
HPRD ID
08471
04234
Ensembl ID
ENSG00000166189
ENSG00000051382
Uniprot IDs
Q86YV9
B4DER4
B4DZI3
P42338
PDB IDs
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?