MUL1 and UBE2R2

Number of citations of the paper that reports this interaction (PubMedID 28763789)
14

Data Source:
BioGRID (pull down)

		MUL1	UBE2R2
Description		mitochondrial E3 ubiquitin protein ligase 1	ubiquitin conjugating enzyme E2 R2
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GO Annotations	Cellular Component	Mitochondrion Peroxisome Membrane Axon Integral Component Of Mitochondrial Outer Membrane Neuronal Cell Body	Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding SUMO Transferase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Metal Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Mitochondrial Fission Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Activation Of JUN Kinase Activity Negative Regulation Of Mitochondrial Fusion Regulation Of Mitochondrion Organization Protein Ubiquitination Protein Sumoylation Negative Regulation Of Cell Growth Protein Destabilization Positive Regulation Of Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Innate Immune Response Negative Regulation Of Defense Response To Virus By Host Protein Stabilization Mitochondrion Localization Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Exogenous DsRNA Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of Mitochondrial Fission Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Dendrite Extension Positive Regulation Of Autophagy Of Mitochondrion In Response To Mitochondrial Depolarization	Protein Monoubiquitination Protein Ubiquitination Protein K48-linked Ubiquitination
Pathways		Ub-specific processing proteases	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Bipolar disorder ( 20351715) Body mass index ( 25673413) Estimated glomerular filtration rate ( 31015462) Health literacy ( 31250787)
Interacting Genes		30 interacting genes: AKT1 APPBP2 CDC34 DNM1L EHD1 HTRA2 MAP3K7 STING1 SUMO1 TAP1 TP53 TP73 TRIM9 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2G2 UBE2L3 UBE2L6 UBE2N UBE2R2 UBE2U UBE2V2 UBE2W ULK1	25 interacting genes: APPBP2 ARHGDIA ARIH2 BTRC CBLC CSNK2A1 CSNK2A2 CTNNB1 CUL3 DTX3L DZIP3 FBXW5 INF2 ITCH MAEA MDM2 MEOX1 MUL1 PNPLA2 PRKN RBX1 RNF113B RNF31 UBA1 UBC
Entrez ID		79594	54926
HPRD ID		07799	15602
Ensembl ID		ENSG00000090432	ENSG00000107341
Uniprot IDs		A1PUM0 Q969V5	Q712K3
PDB IDs		6K2K	6NYO
Enriched GO Terms of Interacting Partners?
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