CDC73 and FSD2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		CDC73	FSD2
Description		cell division cycle 73	fibronectin type III and SPRY domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Cytosol Cdc73/Paf1 Complex	Nucleus Sarcoplasmic Reticulum Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Endodermal Cell Fate Commitment Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter MRNA Polyadenylation Cell Cycle Negative Regulation Of Cell Proliferation Histone Monoubiquitination Wnt Signaling Pathway Protein Ubiquitination Stem Cell Population Maintenance Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of MRNA 3'-end Processing Protein Destabilization Positive Regulation Of Transcription Elongation From RNA Polymerase II Promoter Histone H2B Ubiquitination Recruitment Of 3'-end Processing Factors To RNA Polymerase II Holoenzyme Complex Negative Regulation Of Apoptotic Process Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Fibroblast Proliferation Negative Regulation Of Epithelial Cell Proliferation Cellular Response To Lipopolysaccharide Positive Regulation Of Cell Cycle G1/S Phase Transition Beta-catenin-TCF Complex Assembly Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Formation of RNA Pol II elongation complex Formation of the beta-catenin:TCF transactivating complex Hedgehog 'on' state RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins
Drugs
Diseases		Primary hyperparathyroidism; Familial hyperparathyroidism (HRPT)
GWAS		Chronotype ( 30696823) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Subcutaneous adipose tissue ( 22589738) Takayasu arteritis ( 25604533) White matter hyperintensity burden ( 25663218)	Tourette syndrome ( 30818990)
Interacting Genes		30 interacting genes: ALAS1 ANXA6 CEP70 CTNNB1 DDAH2 FAF1 FSD2 GC GOLGA2 H1-2 HAP1 HSF2BP HSPA4 ITFG1 KASH5 KCNH2 KIAA1549 KIDINS220 MCM3AP MTUS2 MYC PITHD1 RNF40 TCEA1 TCF4 TFCP2 TOMM20 TSGA10 VPS37B WWC1	42 interacting genes: AQP1 BEX2 BEX3 BRD8 CBX8 CCDC112 CCHCR1 CDC73 CORO1A ESD FAM107A FAM161A FAM90A1 FMR1 IFT20 KANSL1 LATS1 LENG1 MRPL11 NDN PBX3 PIK3R3 POLL PPP1R18 PPP2R5D PSMB4 SH2D4A SPATC1L TCEANC TLE5 ZBTB38 ZC2HC1C ZMAT2 ZNF124 ZNF20 ZNF230 ZNF410 ZNF417 ZNF572 ZNF581 ZNF587 ZSCAN26
Entrez ID		79577	123722
HPRD ID		09581	17291
Ensembl ID		ENSG00000134371	ENSG00000186628
Uniprot IDs		Q6P1J9	A1L4K1 B7ZM05
PDB IDs		5YDE 5YDF
Enriched GO Terms of Interacting Partners?
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