EPM2A and TDG

Number of citations of the paper that reports this interaction (PubMedID 26493215)
5

Data Source:
BioGRID (two hybrid)

		EPM2A	TDG
Description		EPM2A glucan phosphatase, laforin	thymine DNA glycosylase
Image
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Plasma Membrane PML Body
	Molecular Function	Protein Binding	Magnesium Ion Binding DNA Binding Damaged DNA Binding Double-stranded DNA Binding Transcription Coregulator Activity Uracil DNA N-glycosylase Activity Protein Kinase C Binding Protein Binding ATP Binding Transcription Factor Binding Pyrimidine-specific Mismatch Base Pair DNA N-glycosylase Activity DNA N-glycosylase Activity Protein Domain Specific Binding Mismatched DNA Binding Sodium Ion Binding Chloride Ion Binding SUMO Binding Protein Homodimerization Activity Protein Self-association G/U Mismatch-specific Uracil-DNA Glycosylase Activity
	Biological Process	Positive Regulation Of Macroautophagy Negative Regulation Of TOR Signaling	Negative Regulation Of Transcription By RNA Polymerase II Base-excision Repair Base-excision Repair, AP Site Formation Mismatch Repair Chromatin Organization Negative Regulation Of Protein Binding Oxidative DNA Demethylation Negative Regulation Of Chromatin Binding Regulation Of Gene Expression, Epigenetic Depyrimidination Regulation Of Embryonic Development DNA Demethylation Regulation Of DNA N-glycosylase Activity
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 SUMOylation of DNA damage response and repair proteins TET1,2,3 and TDG demethylate DNA
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 27863252) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)	Glucagon levels in response to oral glucose tolerance test (fasting) ( 29093273) Metabolite levels ( 23823483)
Interacting Genes		16 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 NHLRC1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS	36 interacting genes: AR CREBBP CRK DDX39B DNMT3B DTL EP300 EPM2A ESR1 HUS1 IKZF1 JUN JUNB MX1 NKX2-1 NR3C1 PCNA PGR PML RAD1 RAD23B RAD9A RXRA SERBP1 SIRT6 SKIL SMAD4 SNIP1 STAT3 SUMO1 SUMO2 SUMO3 THRA UBE2I VDR XPC
Entrez ID		7957	6996
HPRD ID		06345	03251
Ensembl ID		ENSG00000112425	ENSG00000139372
Uniprot IDs		H0UI04 O95278	B4DI29 B4E127 Q13569
PDB IDs		4R30 4RKK	1WYW 2D07 2RBA 3UFJ 3UO7 3UOB 4FNC 4JGC 4XEG 4Z3A 4Z47 4Z7B 4Z7Z 5CYS 5FF8 5HF7 5JXY 5T2W 6U15 6U16 6U17
Enriched GO Terms of Interacting Partners?
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