BIRC7 and CASP7

Number of citations of the paper that reports this interaction (PubMedID 11024045)
60

Data Source:
HPRD (in vitro)

		BIRC7	CASP7
Description		baculoviral IAP repeat containing 7	caspase 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Centrosome Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Enzyme Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Apoptotic Process Activation Of JUN Kinase Activity Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Regulation Of Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Natural Killer Cell Apoptotic Process Inhibition Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process	Proteolysis Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis
Pathways			Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins
Drugs			Fica Emricasan
Diseases
GWAS			Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 27723757 22561518)
Interacting Genes		17 interacting genes: CASP3 CASP7 CASP9 DDX6 DIABLO FAM124B HTRA2 PHF1 POLR1C PTCD3 TLE5 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2I UBE2K	61 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAPT MAX MEF2A MEF2D NEDD4 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SLC30A9 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP
Entrez ID		79444	840
HPRD ID		05761	03457
Ensembl ID		ENSG00000101197	ENSG00000165806
Uniprot IDs		Q96CA5	A0A0A0MRL7 B4DWA2 P55210
PDB IDs		1OXN 1OXQ 1OY7 1TW6 2I3H 2I3I 3F7G 3F7H 3F7I 3GT9 3GTA 3UW5 4AUQ	1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z
Enriched GO Terms of Interacting Partners?
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