TMEM43 and FDFT1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TMEM43	FDFT1
Description		transmembrane protein 43	farnesyl-diphosphate farnesyltransferase 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Endoplasmic Reticulum Golgi Apparatus Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Farnesyl-diphosphate Farnesyltransferase Activity Protein Binding Metal Ion Binding Squalene Synthase Activity
	Biological Process	Nuclear Membrane Organization	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Ergosterol Biosynthetic Process Regulation Of Lipid Metabolic Process Farnesyl Diphosphate Metabolic Process Regulation Of Cholesterol Biosynthetic Process
Pathways			Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)
Drugs			TAK-475
Diseases
GWAS		Heel bone mineral density ( 30598549)	Blood protein levels ( 28240269) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Polycystic ovary syndrome ( 26284813)
Interacting Genes		5 interacting genes: CARD10 FDFT1 GRAMD2B LMNA SIAH1	8 interacting genes: ANXA5 ARL6IP1 CREB3 LMNA RFLNA RUVBL2 SHPRH TMEM43
Entrez ID		79188	2222
HPRD ID		15541	01694
Ensembl ID		ENSG00000170876	ENSG00000079459
Uniprot IDs		A0A024R2F9 Q9BTV4	A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1
PDB IDs			1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA
Enriched GO Terms of Interacting Partners?
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