THTPA and HEY1

		THTPA	HEY1
Description		thiamine triphosphatase	hes related family bHLH transcription factor with YRPW motif 1
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GO Annotations	Cellular Component	Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Magnesium Ion Binding Hydrolase Activity Thiamin-triphosphatase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Protein Dimerization Activity
	Biological Process	Generation Of Precursor Metabolites And Energy Thiamine Metabolic Process Dephosphorylation Thiamine Diphosphate Metabolic Process Thiamine-containing Compound Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Notch Signaling Pathway Anterior/posterior Pattern Specification Positive Regulation Of Gene Expression Cell Differentiation Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Notch Signaling Involved In Heart Development Negative Regulation Of Biomineral Tissue Development Circulatory System Development Negative Regulation Of Transcription Regulatory Region DNA Binding Negative Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation Regulation Of Vasculogenesis
Pathways		Vitamin B1 (thiamin) metabolism	NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription
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Diseases
GWAS
Interacting Genes		7 interacting genes: DPAGT1 GCDH HEY1 METTL17 OR4K5 PDE6B RNASE7	17 interacting genes: ARNT CREBZF FBXW7 GATA1 HES1 HEY2 LAPTM5 MDM2 MYOD1 NTRK3 PLEKHF2 PRKD2 SKIL SMAD3 SMAD9 THTPA TP53
Entrez ID		79178	23462
HPRD ID		15505	04260
Ensembl ID		ENSG00000259431	ENSG00000164683
Uniprot IDs		G3V5Q5 Q9BU02	B4DEI9 Q9Y5J3
PDB IDs		3BHD 3TVL	2DB7
Enriched GO Terms of Interacting Partners?
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