PLEKHF1 and TNNT1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PLEKHF1	TNNT1
Description		pleckstrin homology and FYVE domain containing 1	troponin T1, slow skeletal type
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Lysosome Lysosomal Membrane Endosome Endosome Membrane Perinuclear Region Of Cytoplasm	Cytosol Troponin Complex
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Metal Ion Binding Phosphatidylinositol-4-phosphate Binding	Calcium Ion Binding Protein Binding Tropomyosin Binding Calcium-dependent ATPase Activity Troponin T Binding
	Biological Process	Apoptotic Process Endosome Organization Positive Regulation Of Autophagy Vesicle Organization Protein Localization To Plasma Membrane Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Skeletal Muscle Contraction Muscle Contraction Transition Between Fast And Slow Fiber Muscle Filament Sliding Slow-twitch Skeletal Muscle Fiber Contraction Sarcomere Organization Negative Regulation Of Muscle Contraction Cardiac Muscle Contraction
Pathways			Striated Muscle Contraction
Drugs
Diseases			Nemaline myopathy
GWAS		Body mass index ( 26426971)	Height ( 31562340)
Interacting Genes		3 interacting genes: KIFBP L3MBTL3 TNNT1	61 interacting genes: ARMC8 BLOC1S2 BMPR1B CCDC136 CCDC85B CHD3 DDX5 EEF1G FAF1 FXR2 FYN HAP1 HMGXB4 HSP90AB1 IMMT KAT5 KRT40 LARP1 LDOC1 MARS1 MORF4L1 NACAD NAGK NFE2L2 NINL NSG2 OSBP2 OSM PI4KA PLEKHF1 PNMA1 PPFIA1 PRKG1 PSMC5 SEC31A SERPINA4 SH3GL3 SMAD1 SMAD2 SMURF1 SNW1 TBPL1 TFIP11 TGFBR1 TMEM98 TNNC1 TNNI1 TNNI2 TNNI3 TPM1 TPM3 TRA2A TRIM63 UBE2D1 VIM WDCP ZC3H15 ZKSCAN5 ZMYND19 ZNF250 ZNF768
Entrez ID		79156	7138
HPRD ID		15146	01841
Ensembl ID		ENSG00000166289	ENSG00000105048
Uniprot IDs		B4DWN9 Q96S99	P13805
PDB IDs
Enriched GO Terms of Interacting Partners?
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