TNIP2 and NDUFB9

		TNIP2	NDUFB9
Description		TNFAIP3 interacting protein 2	NADH:ubiquinone oxidoreductase subunit B9
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I
	Molecular Function	Protein Binding Protein Kinase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Protein Binding NADH Dehydrogenase (ubiquinone) Activity
	Biological Process	Apoptotic Process Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Protein Deubiquitination CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of B Cell Activation Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process	Mitochondrial Electron Transport, NADH To Ubiquinone Sensory Perception Of Sound Mitochondrial Respiratory Chain Complex I Assembly
Pathways		MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases	Respiratory electron transport Complex I biogenesis
Drugs			NADH
Diseases
GWAS		Extrinsic epigenetic age acceleration ( 29374233) Multiple sclerosis ( 31604244)
Interacting Genes		25 interacting genes: APP CDKN1A CLK1 EP300 FBXO25 FLNA IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NDUFB9 NFKB1 NFKB2 PSMD9 REL RELA SMARCD1 SMURF1 SRPK2 STK11 TEK TNFAIP3 TSG101 UBC	19 interacting genes: DRC7 ELP1 EYA1 FEZ1 GDF9 HAP1 IMMT MAGEA11 MEF2A OR2D2 PRDM14 PRPF31 PSMB9 RAD54B RBBP6 SH3GL3 TNIP2 UBC XRN1
Entrez ID		79155	4715
HPRD ID		18207	03264
Ensembl ID		ENSG00000168884	ENSG00000147684
Uniprot IDs		D6RGJ2 Q8NFZ5	E9PH64 Q9Y6M9
PDB IDs		5H07	5XTC 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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