PRRG4 and UBE2K

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		PRRG4	UBE2K
Description		proline rich and Gla domain 4	ubiquitin conjugating enzyme E2 K
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Integral Component Of Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane	Cell Nucleus Cytosol Filopodium Tip
	Molecular Function	Molecular_function Calcium Ion Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Binding Ubiquitin-ubiquitin Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Biological_process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Peptidyl-threonine Phosphorylation Free Ubiquitin Chain Polymerization Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Type I Interferon-mediated Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Protein K48-linked Ubiquitination
Pathways			Synthesis of active ubiquitin: roles of E1 and E2 enzymes Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Parkinson's disease (age of onset) ( 19772629)	Plasma amyloid beta peptide concentrations (ABx-40) ( 24535457)
Interacting Genes		7 interacting genes: AOC3 BCL10 HDAC1 HLA-C RBBP8 UBE2K VEGFA	79 interacting genes: AMFR ANAPC11 BARD1 BFAR BIRC7 BIRC8 BRCA1 CASP12 CBLC CDC6 DDI1 DDX58 DIABLO DTX3 DTX3L DZIP3 FZR1 HTT ITCH ITSN1 LRSAM1 MAP3K1 MARCHF3 MARCHF7 MDM2 MID1 MIPOL1 MKRN2 MKRN3 NEDD4L NEDD8 NFKB1 NUB1 PIAS4 PJA1 PRKN PRPF40A PRRG4 RBCK1 RC3H2 REL RING1 RLIM RNF111 RNF114 RNF125 RNF144A RNF167 RNF2 RNF31 RNF32 RNF4 RNF41 RNF5 SENP1 SIAH1 SMURF1 TP53 TRAF7 TRAIP TRIM2 TRIM27 TRIM3 TRIM31 TRIM34 TRIM35 TRIM39 TRIM43 TRIM5 TRIM63 UBA1 UBB UBC UBOX5 UHRF2 USP1 WWP2 ZDHHC17 ZNF384
Entrez ID		79056	3093
HPRD ID		15187	04165
Ensembl ID		ENSG00000135378	ENSG00000078140
Uniprot IDs		A0A0S2Z5N9 Q9BZD6	B3KSH4 B4DIZ2 P61086
PDB IDs			1YLA 2O25 3E46 3F92 3K9O 3K9P 5DFL 6IF1 6JB6 6JB7
Enriched GO Terms of Interacting Partners?
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