CA4 and SLC4A4

Number of citations of the paper that reports this interaction (PubMedID 14567693)
37

Data Source:
HPRD (in vivo, in vitro)

		CA4	SLC4A4
Description		carbonic anhydrase 4	solute carrier family 4 member 4
Image
GO Annotations	Cellular Component	Rough Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Trans-Golgi Network Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Membrane Secretory Granule Membrane Anchored Component Of External Side Of Plasma Membrane Brush Border Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Basolateral Plasma Membrane Spanning Component Of Plasma Membrane Extracellular Exosome
	Molecular Function	Carbonate Dehydratase Activity Protein Binding Zinc Ion Binding	Inorganic Anion Exchanger Activity Protein Binding Sodium:bicarbonate Symporter Activity Symporter Activity Identical Protein Binding
	Biological Process	Bicarbonate Transport	Sodium Ion Transport Inorganic Anion Transport Bicarbonate Transport Sodium Ion Transmembrane Transport Sodium Ion Export Across Plasma Membrane Regulation Of Membrane Potential Positive Regulation Of Glycolytic Process Regulation Of Intracellular PH Transmembrane Transport Anion Transmembrane Transport
Pathways		Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Reversible hydration of carbon dioxide	Bicarbonate transporters Defective SLC4A4 causes renal tubular acidosis, proximal, with ocular abnormalities and mental retardation (pRTA-OA)
Drugs		Methyclothiazide Topiramate Ethoxzolamide Bendroflumethiazide Benzthiazide Cyclothiazide Methazolamide Hydroflumethiazide Acetazolamide Dorzolamide Chlorothiazide Zonisamide Hydrochlorothiazide Trichlormethiazide Diclofenamide Brinzolamide Ellagic Acid Sodium carbonate
Diseases		Retinitis pigmentosa (RP)	Proximal renal tubular acidosis (RTA type 2)
GWAS			Age-related nuclear cataracts ( 24951543) Diastolic blood pressure ( 30578418) Fractional exhaled nitric oxide (childhood) ( 24315451) Heel bone mineral density ( 30598549 28869591) Mosquito bite size ( 28199695) QT interval ( 24952745)
Interacting Genes		5 interacting genes: PIH1D1 PRDX2 SLC4A1 SLC4A3 SLC4A4	5 interacting genes: CA2 CA4 PRKACA SLC4A7 SREBF2
Entrez ID		762	8671
HPRD ID		00261	04516
Ensembl ID		ENSG00000167434	ENSG00000080493
Uniprot IDs		P22748	A5JJ20 Q9Y6R1
PDB IDs		1ZNC 3F7B 3F7U 3FW3 5IPZ 5JN8 5JN9 5JNA 5JNC 5KU6	6CAA
Enriched GO Terms of Interacting Partners?
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