XRCC4 and PNKP

Number of citations of the paper that reports this interaction (PubMedID 15385968)
88

Data Source:
HPRD (in vitro, in vivo)

		XRCC4	PNKP
Description		X-ray repair cross complementing 4	polynucleotide kinase 3'-phosphatase
Image
GO Annotations	Cellular Component	Condensed Chromosome Nucleus Nucleoplasm Cytosol DNA-dependent Protein Kinase-DNA Ligase 4 Complex DNA Ligase IV Complex Nonhomologous End Joining Complex	Nucleus Nucleoplasm Nucleolus Mitochondrion Membrane
	Molecular Function	DNA Binding Protein Binding Protein C-terminus Binding Ligase Activity Identical Protein Binding	Damaged DNA Binding Double-stranded DNA Binding Endonuclease Activity Protein Binding ATP Binding Purine Nucleotide Binding Polynucleotide 3'-phosphatase Activity ATP-dependent Polydeoxyribonucleotide 5'-hydroxyl-kinase Activity Nucleoside Monophosphate Kinase Activity
	Biological Process	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Response To X-ray Immunoglobulin V(D)J Recombination DNA Ligation Involved In DNA Repair Positive Regulation Of Ligase Activity Cellular Response To Lithium Ion Establishment Of Integrated Proviral Latency	Nucleotide-excision Repair, DNA Damage Removal DNA-dependent DNA Replication DNA Repair Response To Oxidative Stress Response To Radiation Negative Regulation Of Protein ADP-ribosylation Dephosphorylation Positive Regulation Of Telomere Maintenance Via Telomerase DNA Damage Response, Detection Of DNA Damage Nucleotide Phosphorylation Nucleoside Monophosphate Phosphorylation Positive Regulation Of Telomerase Activity Nucleic Acid Phosphodiester Bond Hydrolysis Polynucleotide 3' Dephosphorylation Positive Regulation Of Telomere Capping Positive Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		2-LTR circle formation SUMOylation of DNA damage response and repair proteins Nonhomologous End-Joining (NHEJ)	APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Drugs		S-(Dimethylarsenic)Cysteine
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Clozapine-induced agranulocytosis ( 25187353) Diisocyanate-induced asthma ( 25918132) Heel bone mineral density ( 30598549) Osteoarthritis biomarkers ( 25057126) Squamous cell lung carcinoma ( 28604730) Type 2 diabetes ( 25760438) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter integrity (fractional anisotropy) ( 29752348) White matter integrity (mean diffusivity) ( 29752348)
Interacting Genes		19 interacting genes: ACTN1 AHNAK APLF APTX ASTE1 BIN1 CAAP1 CALM1 CHD3 CSNK2A1 FAM9B GZMB IFFO1 LIG4 NBN NHEJ1 PNKP PRKDC VIM	17 interacting genes: APP GZMK IKZF1 KDM1A KRTAP4-12 LMNA MAGEA11 MYOZ1 POLB SMAD5 SUV39H1 TNIP1 TRIM37 XRCC1 XRCC4 ZBTB14 ZNF639
Entrez ID		7518	11284
HPRD ID		15951	09284
Ensembl ID		ENSG00000152422	ENSG00000039650
Uniprot IDs		A0A024RAL0 A0A024RAP0 A0A024RAQ8 Q13426 Q7Z763	Q96T60
PDB IDs		1FU1 1IK9 3II6 3MUD 3Q4F 3RWR 3SR2 3W03 4XA4 5CHX 5CJ0 5CJ4 5E50 5WJ7 5WLZ 6ABO	2BRF 2W3O
Enriched GO Terms of Interacting Partners?
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