XPO1 and ATF2

Number of citations of the paper that reports this interaction (PubMedID 16511568)
47

Data Source:
HPRD (in vivo)

		XPO1	ATF2
Description		exportin 1	activating transcription factor 2
Image
GO Annotations	Cellular Component	Kinetochore Nucleus Nuclear Envelope Annulate Lamellae Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Membrane Protein-containing Complex Intracellular Membrane-bounded Organelle Host Cell Ribonucleoprotein Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Mitochondrial Outer Membrane Site Of Double-strand Break
	Molecular Function	RNA Binding Nuclear Export Signal Receptor Activity Protein Binding Ran GTPase Binding Protein Domain Specific Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Histone Acetyltransferase Activity Protein Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding CAMP Response Element Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Ribosomal Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Ribosomal Small Subunit Export From Nucleus Negative Regulation Of Transcription By RNA Polymerase II Protein Export From Nucleus Nucleocytoplasmic Transport Regulation Of Centrosome Duplication Viral Process Protein Localization To Nucleus Regulation Of Protein Catabolic Process Ribosome Biogenesis Response To Drug Regulation Of MRNA Stability Regulation Of Protein Export From Nucleus MRNA Transport Intracellular Transport Of Virus	Negative Regulation Of Transcription By RNA Polymerase II Outflow Tract Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Response To Osmotic Stress Cellular Response To DNA Damage Stimulus Response To Water Deprivation Positive Regulation Of Gene Expression Negative Regulation Of Angiogenesis Histone Acetylation Intra-S DNA Damage Checkpoint Positive Regulation Of Transforming Growth Factor Beta2 Production Positive Regulation Of Neuron Apoptotic Process Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epithelial Cell Proliferation Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of DNA-binding Transcription Factor Activity Adipose Tissue Development Amelogenesis Positive Regulation Of Cardiac Muscle Myoblast Proliferation Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA NEP/NS2 Interacts with the Cellular Export Machinery Downregulation of TGF-beta receptor signaling Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion Deactivation of the beta-catenin transactivating complex HuR (ELAVL1) binds and stabilizes mRNA RHO GTPases Activate Formins MAPK6/MAPK4 signaling Mitotic Prometaphase Cyclin A/B1/B2 associated events during G2/M transition Estrogen-dependent nuclear events downstream of ESR-membrane signaling EML4 and NUDC in mitotic spindle formation	Transcriptional activation of mitochondrial biogenesis HATs acetylate histones Circadian Clock Activation of the AP-1 family of transcription factors TP53 Regulates Transcription of DNA Repair Genes Regulation of PTEN gene transcription Regulation of PTEN gene transcription Estrogen-dependent gene expression NGF-stimulated transcription NGF-stimulated transcription Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency
Drugs			Pseudoephedrine
Diseases
GWAS		Atrial fibrillation ( 29892015) Eosinophil counts ( 27863252) Erectile dysfunction ( 30583798) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 28714469) Urinary sodium excretion ( 31409800)	Intake of total sugars ( 31005972) Metabolite levels ( 23823483)
Interacting Genes		77 interacting genes: ABL1 ADAR AGFG1 AHR ANP32A ANP32B APC ATF2 BECN1 BIRC5 BRCA2 CCND1 CDC25A CDCA4 CDKN1B CHEK1 CHORDC1 CIITA CRK DDX3X DESI1 DR1 E2F4 E2F5 EIF5A ERF FBXO7 FOXO4 HDAC3 HNF4A HSPA9 HSPB1 IRF5 KIF17 MAPK6 NF2 NMD3 NPM1 NUCB1 NUCB2 NUP153 NUP214 NUP50 NUP62 NXF3 NXT1 ORC1 PHAX PHB PKIA RAD51 RAN RANBP2 RANBP3 RCC1 RCN2 RGS14 RIC8A RPS6KB1 SERPINB1 SERTAD2 SIRT2 SMAD1 SMARCB1 SMURF1 SMURF2 SNUPN SOX2 STAT1 STRADA SUMO1 TERF2IP TERT TOP2A TOP2B TP53 TP73	55 interacting genes: APP AR ATF3 ATF4 ATF7 BACH1 BATF CCDC6 CCND1 CEBPA CEBPB CEBPG CREB5 CSNK2A1 CSNK2A2 DDIT3 DNMT3L EDF1 ETS1 EXOSC8 FOS FOSL1 GTF2F2 H2BC21 HMGA1 IRF2BP1 JDP2 JUN KIFC3 MACROH2A1 MAPK1 MAPK10 MAPK11 MAPK13 MAPK14 MAPK8 MAPK9 MAPKAPK5 MLH1 NBN NCOA6 PML PRKCE RB1 RPS6KA5 RUVBL2 SMAD3 SMAD4 SRA1 SUMO1 THRB UBE2I UTF1 XPO1 YY1
Entrez ID		7514	1386
HPRD ID		03975	00443
Ensembl ID		ENSG00000082898	ENSG00000115966
Uniprot IDs		B3KWD0 O14980	A4D7V5 P15336
PDB IDs		1W9C 2L1L 3GB8 4BSM 4BSN 5DIS	1BHI 1T2K 4H36
Enriched GO Terms of Interacting Partners?
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