XPA and RPA2

Number of citations of the paper that reports this interaction (PubMedID 11081631)
99

Data Source:
HPRD (in vitro)

		XPA	RPA2
Description		XPA, DNA damage recognition and repair factor	replication protein A2
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GO Annotations	Cellular Component	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Intercellular Bridge	Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm DNA Replication Factor A Complex Nuclear Body PML Body Site Of Double-strand Break
	Molecular Function	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Protein Phosphatase Binding Ubiquitin Protein Ligase Binding Protein N-terminus Binding G-rich Strand Telomeric DNA Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition Nucleotide-excision Repair, DNA Duplex Unwinding DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To Oxidative Stress Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Response To Toxic Substance UV Protection Regulation Of Autophagy Response To Auditory Stimulus Nucleotide-excision Repair, DNA Incision Protein Localization To Nucleus Multicellular Organism Growth Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Global Genome Nucleotide-excision Repair UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair	G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Regulation Of Double-strand Break Repair Via Homologous Recombination Translesion Synthesis Mitotic G1 DNA Damage Checkpoint Telomere Maintenance Via Semi-conservative Replication Nucleotide-excision Repair, DNA Incision Protein Localization To Chromosome Interstrand Cross-link Repair Error-prone Translesion Synthesis DNA Damage Response, Detection Of DNA Damage Error-free Translesion Synthesis Regulation Of Cellular Response To Heat Regulation Of Signal Transduction By P53 Class Mediator Regulation Of DNA Damage Checkpoint
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER	Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Removal of the Flap Intermediate from the C-strand Activation of ATR in response to replication stress Regulation of HSF1-mediated heat shock response HSF1 activation Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) PCNA-Dependent Long Patch Base Excision Repair Translesion synthesis by POLK Translesion synthesis by POLI Termination of translesion DNA synthesis HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Formation of Incision Complex in GG-NER Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER Fanconi Anemia Pathway Regulation of TP53 Activity through Phosphorylation Activation of the pre-replicative complex Removal of the Flap Intermediate G2/M DNA damage checkpoint Meiotic recombination
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		25 interacting genes: AP2M1 ATM ATR DDB1 DDB2 ERCC1 ERCC4 ERCC6 GPN1 GTF2E2 GTF2H1 HERC2 MSH2 MSH3 NDEL1 PCNA PRKDC RASSF1 RHOU RPA1 RPA2 RPA4 TRIM27 XAB2 XPC	61 interacting genes: ACP5 AKAP9 APP ATM CALCOCO2 CASK CCNO CDC5L CDK1 CEP126 CFB COPS6 CRMP1 DMRTB1 EEF1A1 EIF4G2 ERCC1 ERCC4 GAPDH GOLM1 HERPUD1 HNRNPUL1 HUS1 LNX2 LRIF1 MARK2 MCM2 MCM5 MED1 MED31 MEN1 NDEL1 ORC1 ORC2 ORC4 ORC5 PCM1 PPP4C PRC1 PRKCI PRKDC RAD1 RAD51 RAD52 RAD9A RBM14 RBM48 RPA1 RPA3 RPLP1 SDF4 SERTAD3 SLC17A9 STAT3 TLE1 TUBB2A UNC119 UNG UTP14A XPA YWHAE
Entrez ID		7507	6118
HPRD ID		02045	01566
Ensembl ID		ENSG00000136936	ENSG00000117748
Uniprot IDs		P23025	B4DUL2 P15927
PDB IDs		1D4U 1XPA 2JNW 6J44 6RO4	1DPU 1L1O 1QUQ 1Z1D 2PI2 2PQA 2Z6K 3KDF 4MQV 4OU0
Enriched GO Terms of Interacting Partners?
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