WNT7B and PORCN

Number of citations of the paper that reports this interaction (PubMedID 10866835)
33

Data Source:
HPRD (in vivo, in vitro)

		WNT7B	PORCN
Description		Wnt family member 7B	porcupine O-acyltransferase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Endocytic Vesicle Membrane Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane AMPA Glutamate Receptor Complex Glutamatergic Synapse
	Molecular Function	Frizzled Binding Protein Binding Receptor Ligand Activity	Wnt-protein Binding Palmitoleoyltransferase Activity
	Biological Process	In Utero Embryonic Development Metanephros Morphogenesis Activation Of JUN Kinase Activity Wnt Signaling Pathway Establishment Or Maintenance Of Polarity Of Embryonic Epithelium Forebrain Regionalization Central Nervous System Vasculogenesis Neuron Differentiation Lung Development Oxygen Homeostasis Regulation Of Cell Projection Size Homeostatic Process Cellular Metabolic Process Cell Fate Commitment Positive Regulation Of Osteoblast Differentiation Positive Regulation Of JNK Cascade Fibroblast Proliferation Embryonic Organ Development Neuron Projection Morphogenesis Synapse Organization Response To Glucocorticoid Canonical Wnt Signaling Pathway Lung Morphogenesis Lung Epithelium Development Lobar Bronchus Development Trachea Cartilage Morphogenesis Developmental Growth Involved In Morphogenesis Embryonic Placenta Morphogenesis Chorio-allantoic Fusion Mammary Gland Epithelium Development Lens Fiber Cell Development Cellular Response To Retinoic Acid Renal Inner Medulla Development Renal Outer Medulla Development Outer Medullary Collecting Duct Development Inner Medullary Collecting Duct Development Stem Cell Proliferation Metanephric Collecting Duct Development Metanephric Epithelium Development Metanephric Loop Of Henle Development	Protein Lipidation Glycoprotein Metabolic Process Wnt Signaling Pathway Protein Palmitoleylation Canonical Wnt Signaling Pathway Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors)	WNT ligand biogenesis and trafficking WNT ligand secretion is abrogated by the PORCN inhibitor LGK974
Drugs
Diseases			Focal dermal hypoplasia; Goltz-Gorlin syndrome
GWAS		Body mass index ( 25760438) Central corneal thickness ( 28171582 29847655) Corneal curvature ( 25823570) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) Macular thickness ( 30535121) Optic disc size ( 31809533) Red blood cell count ( 27863252) Rosacea symptom severity ( 29771307)
Interacting Genes		5 interacting genes: CASK CUL3 ELOC GPC3 PORCN	6 interacting genes: WNT1 WNT3A WNT4 WNT5B WNT6 WNT7B
Entrez ID		7477	64840
HPRD ID		03573	06680
Ensembl ID		ENSG00000188064	ENSG00000102312
Uniprot IDs		A8K0G1 P56706	Q9H237
PDB IDs
Enriched GO Terms of Interacting Partners?
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