VTN and ITGA8

Number of citations of the paper that reports this interaction (PubMedID 7559467)
51

Data Source:
HPRD (in vitro)

		VTN	ITGA8
Description		vitronectin	integrin subunit alpha 8
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Space Endoplasmic Reticulum Golgi Lumen Intracellular Membrane-bounded Organelle Rough Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Alphav-beta3 Integrin-vitronectin Complex Blood Microparticle	Endoplasmic Reticulum Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Postsynaptic Density Dendritic Spine Membrane Integrin Alpha8-beta1 Complex Perikaryon Apical Part Of Cell
	Molecular Function	Scavenger Receptor Activity Integrin Binding Extracellular Matrix Structural Constituent Protein Binding Collagen Binding Heparin Binding Polysaccharide Binding Identical Protein Binding Extracellular Matrix Binding	Metal Ion Binding
	Biological Process	Endocytosis Immune Response Cell Adhesion Cell-matrix Adhesion Positive Regulation Of Cell-substrate Adhesion Negative Regulation Of Endopeptidase Activity Positive Regulation Of Smooth Muscle Cell Migration Cell Migration Negative Regulation Of Blood Coagulation Extracellular Matrix Organization Regulation Of Complement Activation Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Binding Cell Adhesion Mediated By Integrin Endodermal Cell Differentiation Positive Regulation Of Receptor-mediated Endocytosis Oligodendrocyte Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Protein Polymerization Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Wound Healing Liver Regeneration	Metanephros Development Kidney Development Cell-matrix Adhesion Integrin-mediated Signaling Pathway Brain Development Memory Cell Projection Organization Extracellular Matrix Organization Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Inner Ear Morphogenesis Establishment Of Protein Localization Mesodermal Cell Differentiation Smooth Muscle Tissue Development Cell-cell Adhesion Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Smooth Muscle Cell Differentiation
Pathways		Molecules associated with elastic fibres Integrin cell surface interactions Syndecan interactions ECM proteoglycans ECM proteoglycans Regulation of Complement cascade	Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions ECM proteoglycans
Drugs		Abciximab Zinc Copper
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Blood protein levels ( 30072576 29875488 28240269) Heel bone mineral density ( 30598549) LDL cholesterol ( 30275531) Osteoprotegerin levels ( 25080503)	Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Diisocyanate-induced asthma ( 25918132) Parkinson's disease ( 19915575) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Periodontitis (CDC/AAP) ( 24024966) Quantitative traits ( 19197348) Smoking status (heavy vs never) ( 26423011)
Interacting Genes		43 interacting genes: ADH5 ADTRP AMPH APP CBX1 CD247 CKS2 COPS5 CRADD CSNK2A1 EGF ETV7 FGF2 FGG GEM GLUD1 GOPC HGF IGF2 IGFBP5 ITGA8 ITGB3 ITGB6 ITGB8 KNG1 LACRT LNX2 PLAUR POMC PRDX4 PRKACA PRKCA PRKCB PRKCG PVR RHOXF1 RPL13A SERPINE1 SIX1 TGFB1 TGFB2 TNFRSF11B VEGFA	4 interacting genes: FN1 ITGB1 NPNT VTN
Entrez ID		7448	8516
HPRD ID		01902	10361
Ensembl ID		ENSG00000109072	ENSG00000077943
Uniprot IDs		D9ZGG2 P04004	B4DN28 P53708
PDB IDs		1OC0 1S4G 1SSU 2JQ8 3BT1 3BT2 4K24 6O5E
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?