MPPED2 and RXRG

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MPPED2	RXRG
Description		metallophosphoesterase domain containing 2	retinoid X receptor gamma
Image		No pdb structure
GO Annotations	Cellular Component		Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Protein Binding Phosphoric Diester Hydrolase Activity AMP Binding GMP Binding Manganese Ion Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoic Acid-responsive Element Binding
	Biological Process		Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Response To Retinoic Acid Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development
Pathways			Nuclear Receptor transcription pathway Signaling by Retinoic Acid
Drugs			Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Etretinate Bezafibrate Phthalic Acid Doconexent
Diseases
GWAS		Adventurousness ( 30643258) Asthma ( 27611488) Automobile speeding propensity ( 30643258) Blood urea nitrogen levels ( 29403010) Chronic kidney disease ( 22479191 26831199) Chronotype ( 30696823) Creatinine levels ( 29403010) Dental caries ( 21940522) Estimated glomerular filtration rate ( 31015462 30604766) Glomerular filtration rate ( 27588450 29403010) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Major depressive disorder ( 27479909) Medication use (diuretics) ( 31015401) Migraine ( 27322543) Morning person ( 30696823) Pit-and-Fissure caries ( 24556642) Renal function-related traits (eGRFcrea) ( 22797727) Renal function-related traits (sCR) ( 22797727) Serum uric acid levels ( 30993211 29403010) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30578418) Urate levels ( 31578528)	AIDS ( 19754311) Bipolar disorder (age of onset <21) or attention deficit hyperactivity disorder ( 27890468) Bipolar disorder or attention deficit hyperactivity disorder ( 27890468) Macular thickness ( 30535121) Menarche (age at onset) ( 27182965 21102462 29773799 25231870) Metabolite levels ( 23823483) Personality traits in bipolar disorder ( 21368711)
Interacting Genes		7 interacting genes: CAGE1 FAM72A IKZF1 NOTCH3 RXRG TRIP13 VAC14	29 interacting genes: CAMK2B CEBPZ CHGB CREBBP DCK HOXD4 ITGB3BP LRSAM1 MAP4 MPPED2 NCOA6 NCOR2 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR4A1 PNO1 PPARA PPARD PPARG RARA RARB RARG SRF THRA THRB VDR
Entrez ID		744	6258
HPRD ID		02947	01579
Ensembl ID		ENSG00000066382	ENSG00000143171
Uniprot IDs		Q15777	A0A087WZ88 F1D8Q7 F1T097 P48443
PDB IDs			2GL8
Enriched GO Terms of Interacting Partners?
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